diff --git a/docker/Dockerfile b/docker/Dockerfile
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+FROM ghcr.io/charlenelawdes/hmmer-docker AS hmmer-builder
+FROM ghcr.io/charlenelawdes/prodigal-docker AS prodigal-builder
+FROM ghcr.io/charlenelawdes/sklearn-docker AS sklearn-builder
+
+FROM debian:bullseye
+RUN apt-get update && apt-get install -y \
+    git \
+    gcc \
+    python3 \
+    cython3 \
+    python3-biopython \
+    python3-matplotlib \
+    python3-pandas \
+    python3-seaborn \
+    python3-pip \
+    wget
+
+# Copy executables from builder images
+COPY --from=hmmer-builder /usr/local/bin/ /usr/local/bin/
+COPY --from=prodigal-builder /usr/local/bin/ /usr/local/bin/
+
+# Install scikit-learn for build stage with the version required by VIBRANT
+RUN pip3 install -U scikit-learn==0.21.3
+
+# Install VIBRANT
+RUN git clone https://github.com/AnantharamanLab/VIBRANT
+RUN chmod -R 777 VIBRANT
+
+# Setup the databases files 
+WORKDIR /VIBRANT/databases
+
+
+RUN wget http://fileshare.csb.univie.ac.at/vog/vog94/vog.hmm.tar.gz && \
+    wget ftp://ftp.ebi.ac.uk/pub/databases/Pfam/releases/Pfam32.0/Pfam-A.hmm.gz && \
+    wget ftp://ftp.genome.jp/pub/db/kofam/archives/2019-08-10/profiles.tar.gz
+
+
+RUN tar -xzf vog.hmm.tar.gz && \
+    gunzip Pfam-A.hmm.gz && \
+    tar -xzf profiles.tar.gz
+
+
+RUN cat VOG*.hmm > vog_temp.HMM && \
+    cat profiles/K*.hmm > kegg_temp.HMM
+
+
+RUN rm VOG0*.hmm VOG1*.hmm VOG2*.hmm && \
+    rm -R profiles
+
+
+RUN hmmfetch -o VOGDB94_phage.HMM -f vog_temp.HMM profile_names/VIBRANT_vog_profiles.txt && \
+    hmmfetch -o KEGG_profiles_prokaryotes.HMM -f kegg_temp.HMM profile_names/VIBRANT_kegg_profiles.txt && \
+    mv Pfam-A.hmm Pfam-A_v32.HMM
+
+
+RUN rm vog_temp.HMM kegg_temp.HMM vog.hmm.tar.gz profiles.tar.gz
+
+
+RUN hmmpress VOGDB94_phage.HMM && \
+    hmmpress KEGG_profiles_prokaryotes.HMM && \
+    hmmpress Pfam-A_v32.HMM
+
+# Verify databases and dependencies
+RUN python3 VIBRANT_setup.py -test
+
+# Set the working directory back to /VIBRANT
+WORKDIR /VIBRANT