diff --git a/bindings/profilers/heap.cc b/bindings/profilers/heap.cc
index fa81f742..a577b7fb 100644
--- a/bindings/profilers/heap.cc
+++ b/bindings/profilers/heap.cc
@@ -661,6 +661,8 @@ void InterruptCallback(v8::Isolate* isolate, void* data) {
       dd::TranslateAllocationProfile(state->profile.get())};
   Nan::AsyncResource resource("NearHeapLimit");
   state->callback.Call(1, argv, &resource);
+  // Release the retained native profile once the callback has been invoked.
+  state->profile.reset();
 }
 
 void AsyncCallback(uv_async_t* handle) {