Bias_weight is malformed. It should control the weight of bias vs. imprecision when optimizing the dose, not the weight of the prior vs. the posterior.
At least for BestDose in Pmetrics, it would be ideal to use the same calculations for bias and imprecision as specified in the user options, i.e. those set by setPMoptions(). If this is too complex, I would use weighted mean pred-obs for bias, and the square of that for imprecision.
Bias_weight is malformed. It should control the weight of bias vs. imprecision when optimizing the dose, not the weight of the prior vs. the posterior.
At least for BestDose in Pmetrics, it would be ideal to use the same calculations for bias and imprecision as specified in the user options, i.e. those set by setPMoptions(). If this is too complex, I would use weighted mean pred-obs for bias, and the square of that for imprecision.