Hi!
I’ve been following the tutorial using Xenium data from 5 TMA cores, with fewer than 500 genes. However, the disentanglement plots I obtained after training look quite different from those shown in the tutorial. It seems like the disentanglement wasn’t successful.
Could you help me figure out what might be going wrong?
Could the issue be that 20 epochs (as used in the tutorial) weren’t enough?
Or is the limited number of genes (<500) potentially causing problems?
I’ve also tried plotting results from different epochs, but the issue persists.

Hi!
I’ve been following the tutorial using Xenium data from 5 TMA cores, with fewer than 500 genes. However, the disentanglement plots I obtained after training look quite different from those shown in the tutorial. It seems like the disentanglement wasn’t successful.
Could you help me figure out what might be going wrong?
Could the issue be that 20 epochs (as used in the tutorial) weren’t enough?
Or is the limited number of genes (<500) potentially causing problems?
I’ve also tried plotting results from different epochs, but the issue persists.