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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>Menden Lab - Research & Innovation</title>
<link rel="stylesheet" href="styles.css">
<link rel="preconnect" href="https://fonts.googleapis.com">
<link rel="preconnect" href="https://fonts.gstatic.com" crossorigin>
<link href="https://fonts.googleapis.com/css2?family=Inter:ital,opsz,wght@0,14..32,100..900;1,14..32,100..900&family=Montserrat:ital,wght@0,100..900;1,100..900&display=swap" rel="stylesheet">
</head>
<body>
<!-- Navigation -->
<nav class="navbar">
<div class="container">
<div class="nav-brand">
<h2>Menden Lab</h2>
</div>
<ul class="nav-menu">
<li><a href="#home" class="nav-link">Home</a></li>
<li><a href="#research" class="nav-link">Research</a></li>
<li><a href="#publications" class="nav-link">Publications</a></li>
<li><a href="#projects" class="nav-link">Projects</a></li>
<li><a href="#team" class="nav-link">Team</a></li>
<li><a href="#apply" class="nav-link btn-apply">Contact us</a></li>
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<!-- Hero Section -->
<section id="home" class="hero">
<div class="container">
<div class="hero-content">
<div class="hero-text">
<h1>Biostatistics and AI/ML for <span class="highlight">Drug Discovery</span></h1>
<p class="hero-subtitle">Developing machine learning frameworks to understand complex diseases and identify novel therapies.</p>
<div class="hero-buttons">
<a href="#research" class="btn btn-primary">Explore Our Research</a>
<a href="#apply" class="btn btn-secondary">Join Our Team</a>
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<video class="hero-gif" autoplay muted loop playsinline preload="metadata" aria-label="Menden Lab Research animation">
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<!-- Research Focus Section -->
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<h2>Our Research Focus</h2>
<p>Empowering the next generation of drug target identification, drug repositioning and precision medicine</p>
</div>
<!-- Mission Statement -->
<div class="mission-statement">
<p>The mission of our research group is to develop <strong>biostatistical and machine learning frameworks</strong> applied to biomedical data, to retrieve insights in the aetiology of complex diseases and identify novel intervention strategies. For this, we explore deep molecular characterised biomedical datasets, environmental factors, and tailor our models depending on disease specific knowledge gained through collaborations, literature and data driven analyses, thus empowering the next generation of drug target identification, drug repositioning and precision medicine.</p>
</div>
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<div class="research-card featured-research">
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<svg xmlns="http://www.w3.org/2000/svg" width="200" height="200" viewBox="0 0 24 24"><path fill="#ffffff" d="M8 22q-2.075 0-3.538-1.463T3 17V8q-.825 0-1.413-.588T1 6V4q0-.825.588-1.413T3 2h10q.825 0 1.413.588T15 4v2q0 .825-.588 1.413T13 8v3.025q-1.05.675-1.788 1.688T10.175 15H8v-2h3v-1H8v-2h3V8H5v9q0 1.25.875 2.125T8 20q.75 0 1.375-.325t1.05-.9q.2.5.45.95t.6.875q-.675.65-1.563 1.025T8 22Zm0-4v-2h2.025q-.05.5-.013 1t.163 1H8Zm8.5 1q1.05 0 1.775-.725T19 16.5q0-1.05-.725-1.775T16.5 14q-1.05 0-1.775.725T14 16.5q0 1.05.725 1.775T16.5 19Zm5.1 4l-2.7-2.7q-.55.35-1.15.525T16.5 21q-1.875 0-3.187-1.313T12 16.5q0-1.875 1.313-3.188T16.5 12q1.875 0 3.188 1.313T21 16.5q0 .65-.175 1.25T20.3 18.9l2.7 2.7l-1.4 1.4Z"/></svg>
</div>
<h3>Computational Cancer Pharmacogenomics</h3>
<p>We have strong expertise in computational method development for cancer pharmacogenomics including the analysis of monotherapy and drug combination high-throughput screens, and CRISPR lethality and drug resistance screens, which is highlighted by our <strong>ERC project</strong> and publication record.</p>
<p>The Menden Lab customises machine learning and biostatistical methods to predict drug sensitivity and synergy, as well as derived genetic biomarkers of these responses. Our work focuses on clinical translatability for enabling patient stratification based on deep molecular profiles, which is the key pillar of precision medicine.</p>
</div>
<div class="research-card featured-research">
<div class="research-icon">
<svg xmlns="http://www.w3.org/2000/svg" width="200" height="200" viewBox="0 0 24 24" fill="#ffffff"><g fill="#ffffff"><path fill-rule="evenodd" d="M5.621 3.664c.629-1.064 2.203-.954 2.677.187l2.524 6.073a1.5 1.5 0 0 1-1.49 2.072l-5.868-.41a1.5 1.5 0 0 1-1.187-2.26zm-1.21 5.983l4.253.297l-1.83-4.402z" clip-rule="evenodd"/><path d="M15.759 5.284a1 1 0 1 0-.518 1.932l1.932.518a1 1 0 1 0 .518-1.932z"/><path fill-rule="evenodd" d="M16.5 2a4.5 4.5 0 1 0 0 9a4.5 4.5 0 0 0 0-9M14 6.5a2.5 2.5 0 1 1 5 0a2.5 2.5 0 0 1-5 0M6.238 19.335a3.75 3.75 0 0 1 2.242-4.807l6.108-2.223a3.75 3.75 0 1 1 2.565 7.048l-6.108 2.223a3.75 3.75 0 0 1-4.807-2.241m6.908-4.377l2.126-.774a1.75 1.75 0 0 1 1.197 3.29l-2.126.773zm-1.88.684l-2.102.766a1.75 1.75 0 1 0 1.197 3.288l2.103-.765z" clip-rule="evenodd"/></g></svg>
</div>
<h3>Translational Computational Pharmacogenomics</h3>
<p>The foundation of our endeavour is our strong expertise in Computational Cancer Pharmacogenomics (ERC StG), which we envision to generalise to Translational Computational Pharmacogenomics.</p>
<p>In particular, we expand our research focus to:</p>
<ul class="research-list">
<li><strong>Tuberculosis drug resistance</strong> (bayresq.net, UNITE4TB)</li>
<li><strong>Inflammatory skin diseases</strong> (IGSSE)</li>
<li><strong>Neurodegenerative diseases</strong> (JPND, MUDS)</li>
<li><strong>Diabetes research</strong> (DZD)</li>
</ul>
<p>Common across all projects, we are experts in analysing biological models which are deep molecularly and phenotypic characterised, which ultimately enables precision medicine. In essence, our research vision is to establish a Translational Computational Pharmacogenomics programme in cancer and beyond, in order to accelerate the delivery of urgently needed targeted therapies.</p>
</div>
</div>
</div>
</section>
<!-- Recent Works Section -->
<section id="publications" class="recent-works-section">
<div class="container">
<div class="section-header">
<h2>Key Recent Publications</h2>
</div>
<div class="recent-works" aria-labelledby="recent-works-title">
<div class="recent-works-carousel" aria-label="Recent publications from MendenLab">
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href="https://scholar.google.com/citations?hl=en&user=jBejY7cAAAAJ&view_op=list_works&sortby=pubdate"
class="btn btn-outline"
target="_blank"
rel="noreferrer"
>View all works on Google Scholar</a>
</div>
</div>
</div>
</section>
<!-- Projects Section -->
<section id="projects" class="projects">
<div class="container">
<div class="section-header">
<h2>Featured Projects</h2>
<p>Open-source tools and research initiatives driving scientific discovery</p>
</div>
<div class="projects-carousel" aria-label="Featured repositories from MendenLab">
<button class="projects-carousel-control projects-carousel-control--prev" type="button" aria-label="Previous featured project">
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<a href="https://github.com/MendenLab" class="btn btn-outline" target="_blank">View All Projects on GitHub</a>
</div>
</div>
</section>
<!-- Team Section -->
<section id="team" class="team">
<div class="container">
<div class="section-header">
<h2>Our Team</h2>
</div>
<div class="team-photo-container">
<img src="media/team.JPG" alt="Menden Lab Team" class="team-group-photo">
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<div class="team-featured-content">
<h3 class="team-directory-title">A/Prof Michael Menden</h3>
<p class="team-featured-role">Head of Laboratory</p>
<a href="#" class="team-featured-link">Faculty Page</a>
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<div class="team-info">
<h3>Dr Göksu Avar</h3>
<p class="team-role">Postdoctoral Fellow</p>
</div>
</article>
<article class="team-card" data-team-category="all phd">
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<div class="team-info">
<h3>Alina J Arneth</h3>
<p class="team-role">PhD student</p>
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<div class="team-info">
<h3>Xixi Li</h3>
<p class="team-role">PhD student</p>
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</article>
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<div class="team-info">
<h3>Linpeng Xie</h3>
<p class="team-role">PhD student</p>
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<h3>Xuan Liu</h3>
<p class="team-role">PhD student</p>
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<h3>Qiyang Wu</h3>
<p class="team-role">PhD student</p>
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<h3>Daksh Pamar</h3>
<p class="team-role">PhD student</p>
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<h3>Wenjie Shan</h3>
<p class="team-role">PhD student</p>
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<h3>Chen Gong</h3>
<p class="team-role">PhD student</p>
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<h3>Anthony Basilone</h3>
<p class="team-role">PhD student</p>
</div>
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<h3>Liam Mcinerney</h3>
<p class="team-role">Masters student</p>
</div>
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<div class="team-info">
<h3>I Putu Prakasa Wiprayoga</h3>
<p class="team-role">Masters student</p>
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<div class="team-info">
<h3>Keisuke Yasuda</h3>
<p class="team-role">Masters student</p>
</div>
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<span>Department of Biochemistry and Pharmacology<br>The University Melbourne<br>Melbourne, Australia</span>
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