diff --git a/.github/workflows/continuous_integration.yml b/.github/workflows/continuous_integration.yml
index d568c0557..7a7e36273 100644
--- a/.github/workflows/continuous_integration.yml
+++ b/.github/workflows/continuous_integration.yml
@@ -90,7 +90,6 @@ jobs:
         ls -la
 
     - name: Enable PC Sampling
-      if: ${{ contains(matrix.runner, 'mi200') || contains(matrix.runner, 'mi300a') }}
       shell: bash
       run: |
           echo 'ROCPROFILER_PC_SAMPLING_BETA_ENABLED=1' >> $GITHUB_ENV
@@ -224,7 +223,6 @@ jobs:
         ls -la
 
     - name: Enable PC Sampling
-      if: ${{ contains(matrix.runner, 'mi200') || contains(matrix.runner, 'mi300a') }}
       shell: bash
       run: |
           echo 'ROCPROFILER_PC_SAMPLING_BETA_ENABLED=1' >> $GITHUB_ENV
@@ -295,7 +293,6 @@ jobs:
         ls -la
 
     - name: Enable PC Sampling
-      if: ${{ contains(matrix.runner, 'mi200') || contains(matrix.runner, 'mi300a') }}
       shell: bash
       run: |
           echo 'ROCPROFILER_PC_SAMPLING_BETA_ENABLED=1' >> $GITHUB_ENV
diff --git a/samples/pc_sampling/CMakeLists.txt b/samples/pc_sampling/CMakeLists.txt
index c3fbf54f7..f54548002 100644
--- a/samples/pc_sampling/CMakeLists.txt
+++ b/samples/pc_sampling/CMakeLists.txt
@@ -50,6 +50,15 @@ rocprofiler_samples_get_ld_library_path_env(LIBRARY_PATH_ENV)
 # Check if PC sampling is disabled and whether we should disable the test
 rocprofiler_sdk_pc_sampling_disabled(IS_PC_SAMPLING_DISABLED)
 
+# For some reason, ThreadSanitizer reports a lock-order-invervsion error when running the
+# transpose application standalone. Thus, we disable ThreadSanitizer on PC sampling tests
+# that are using transpose application.
+if(IS_PC_SAMPLING_DISABLED OR ROCPROFILER_MEMCHECK STREQUAL "ThreadSanitizer")
+    set(IS_DISABLED ON)
+else()
+    set(IS_DISABLED OFF)
+endif()
+
 set(pc-sampling-env ${PRELOAD_ENV} ${LIBRARY_PATH_ENV})
 
 add_test(NAME pc-sampling COMMAND $<TARGET_FILE:pc-sampling>)
@@ -67,4 +76,4 @@ set_tests_properties(
                SKIP_REGULAR_EXPRESSION
                "PC sampling unavailable"
                DISABLED
-               "${IS_PC_SAMPLING_DISABLED}")
+               "${IS_DISABLED}")
diff --git a/tests/rocprofv3/pc-sampling/host-trap/transpose-multiple-agents/CMakeLists.txt b/tests/rocprofv3/pc-sampling/host-trap/transpose-multiple-agents/CMakeLists.txt
index 6851871ca..086e9e4e6 100644
--- a/tests/rocprofv3/pc-sampling/host-trap/transpose-multiple-agents/CMakeLists.txt
+++ b/tests/rocprofv3/pc-sampling/host-trap/transpose-multiple-agents/CMakeLists.txt
@@ -13,6 +13,15 @@ find_package(rocprofiler-sdk REQUIRED)
 # Check if PC sampling is disabled and whether we should skip the tests.
 rocprofiler_sdk_pc_sampling_disabled(IS_PC_SAMPLING_DISABLED)
 
+# For some reason, ThreadSanitizer reports a lock-order-invervsion error when running the
+# transpose application standalone. Thus, we disable ThreadSanitizer on PC sampling tests
+# that are using transpose application.
+if(IS_PC_SAMPLING_DISABLED OR ROCPROFILER_MEMCHECK STREQUAL "ThreadSanitizer")
+    set(IS_DISABLED ON)
+else()
+    set(IS_DISABLED OFF)
+endif()
+
 rocprofiler_configure_pytest_files(CONFIG pytest.ini COPY validate.py conftest.py
                                                           input.json input.yml)
 
@@ -48,7 +57,7 @@ set_tests_properties(
                SKIP_REGULAR_EXPRESSION
                "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
                DISABLED
-               "${IS_PC_SAMPLING_DISABLED}")
+               "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-host-trap-transpose-multiple-agents-input-json-execute
@@ -71,7 +80,7 @@ set_tests_properties(
                SKIP_REGULAR_EXPRESSION
                "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
                DISABLED
-               "${IS_PC_SAMPLING_DISABLED}")
+               "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-host-trap-transpose-multiple-agents-input-yaml-execute
@@ -94,7 +103,7 @@ set_tests_properties(
                SKIP_REGULAR_EXPRESSION
                "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
                DISABLED
-               "${IS_PC_SAMPLING_DISABLED}")
+               "${IS_DISABLED}")
 
 # ========================= Validation tests
 
@@ -123,7 +132,7 @@ set_tests_properties(
         SKIP_REGULAR_EXPRESSION
         "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
         DISABLED
-        "${IS_PC_SAMPLING_DISABLED}")
+        "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-host-trap-transpose-multiple-agents-input-json-validate
@@ -150,7 +159,7 @@ set_tests_properties(
         SKIP_REGULAR_EXPRESSION
         "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
         DISABLED
-        "${IS_PC_SAMPLING_DISABLED}")
+        "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-host-trap-transpose-multiple-agents-input-yaml-validate
@@ -177,4 +186,4 @@ set_tests_properties(
         SKIP_REGULAR_EXPRESSION
         "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
         DISABLED
-        "${IS_PC_SAMPLING_DISABLED}")
+        "${IS_DISABLED}")
diff --git a/tests/rocprofv3/pc-sampling/stochastic/transpose-multiple-agents/CMakeLists.txt b/tests/rocprofv3/pc-sampling/stochastic/transpose-multiple-agents/CMakeLists.txt
index ca88e6567..b2d349ea9 100644
--- a/tests/rocprofv3/pc-sampling/stochastic/transpose-multiple-agents/CMakeLists.txt
+++ b/tests/rocprofv3/pc-sampling/stochastic/transpose-multiple-agents/CMakeLists.txt
@@ -35,6 +35,15 @@ find_package(rocprofiler-sdk REQUIRED)
 # Checking whether stochastic PC sampling is disabled. If so, skip the tests.
 rocprofiler_sdk_pc_sampling_stochastic_disabled(IS_PC_SAMPLING_STOCHASTIC_DISABLED)
 
+# For some reason, ThreadSanitizer reports a lock-order-invervsion error when running the
+# transpose application standalone. Thus, we disable ThreadSanitizer on PC sampling tests
+# that are using transpose application.
+if(IS_PC_SAMPLING_DISABLED OR ROCPROFILER_MEMCHECK STREQUAL "ThreadSanitizer")
+    set(IS_DISABLED ON)
+else()
+    set(IS_DISABLED OFF)
+endif()
+
 rocprofiler_configure_pytest_files(CONFIG pytest.ini COPY validate.py conftest.py
                                                           input.json input.yml)
 
@@ -70,7 +79,7 @@ set_tests_properties(
                SKIP_REGULAR_EXPRESSION
                "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
                DISABLED
-               "${IS_PC_SAMPLING_STOCHASTIC_DISABLED}")
+               "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-stochastic-transpose-multiple-agents-input-json-execute
@@ -93,7 +102,7 @@ set_tests_properties(
                SKIP_REGULAR_EXPRESSION
                "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
                DISABLED
-               "${IS_PC_SAMPLING_STOCHASTIC_DISABLED}")
+               "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-stochastic-transpose-multiple-agents-input-yaml-execute
@@ -116,7 +125,7 @@ set_tests_properties(
                SKIP_REGULAR_EXPRESSION
                "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
                DISABLED
-               "${IS_PC_SAMPLING_STOCHASTIC_DISABLED}")
+               "${IS_DISABLED}")
 
 # ========================= Validation tests
 
@@ -147,7 +156,7 @@ set_tests_properties(
         SKIP_REGULAR_EXPRESSION
         "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
         DISABLED
-        "${IS_PC_SAMPLING_STOCHASTIC_DISABLED}")
+        "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-stochastic-transpose-multiple-agents-input-json-validate
@@ -176,7 +185,7 @@ set_tests_properties(
         SKIP_REGULAR_EXPRESSION
         "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
         DISABLED
-        "${IS_PC_SAMPLING_STOCHASTIC_DISABLED}")
+        "${IS_DISABLED}")
 
 add_test(
     NAME rocprofv3-test-pc-sampling-stochastic-transpose-multiple-agents-input-yaml-validate
@@ -205,4 +214,4 @@ set_tests_properties(
         SKIP_REGULAR_EXPRESSION
         "${ROCPROFV3_TESTS_PC_SAMPLING_SKIP_REGEX}"
         DISABLED
-        "${IS_PC_SAMPLING_STOCHASTIC_DISABLED}")
+        "${IS_DISABLED}")