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Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo

Contents

data: Raw and processed datasets

cross-validation: Scripts for running cross-validation on luciferase expression data using various machine learning models.

figures: Includes a notebook for generating all machine learning-related figures.

Citation

@article {Han2025plug,
	author = {Han, Xuexiang and Xu, Ying and Ricciardi, Adele and Xu, Junchao and Palanki, Rohan and Chowdhary, Vivek and Xue, Lulu and Gong, Ningqiang and Alameh, Mohamad-Gabriel and Peranteau, William H. and Wilson, James M. and Weissman, Drew and Mitchell, Michael J.},
	title = {Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo},
	elocation-id = {2025.02.25.640222},
	year = {2025},
	doi = {10.1101/2025.02.25.640222},
	publisher = {Cold Spring Harbor Laboratory},
	URL = {https://www.biorxiv.org/content/early/2025/03/01/2025.02.25.640222},
	eprint = {https://www.biorxiv.org/content/early/2025/03/01/2025.02.25.640222.full.pdf},
	journal = {bioRxiv}
}