diff --git a/src/recyclerview/RecyclerView.tsx b/src/recyclerview/RecyclerView.tsx
index 3c25e7e89..0735009a1 100644
--- a/src/recyclerview/RecyclerView.tsx
+++ b/src/recyclerview/RecyclerView.tsx
@@ -52,6 +52,7 @@ import { getInvertedTransformStyle } from "./utils/getInvertedTransformStyle";
 import { StickyHeaders, StickyHeaderRef } from "./components/StickyHeaders";
 import { ScrollAnchor, ScrollAnchorRef } from "./components/ScrollAnchor";
 import { useRecyclerViewController } from "./hooks/useRecyclerViewController";
+import { useInvertedWheelFix } from "./hooks/useInvertedWheelFix";
 import { RenderTimeTracker } from "./helpers/RenderTimeTracker";
 
 /**
@@ -483,6 +484,9 @@ const RecyclerViewComponent = <T,>(
     return onScrollHandler;
   }, [onScrollHandler, scrollY, stickyHeaders, stickyHeaderUseNativeDriver]);
 
+  // Re-invert mouse-wheel direction for inverted lists on web (no-op native).
+  useInvertedWheelFix(scrollViewRef, inverted, horizontal);
+
   const shouldMaintainVisibleContentPosition =
     recyclerViewManager.shouldMaintainVisibleContentPosition();
 
diff --git a/src/recyclerview/hooks/useInvertedWheelFix.ts b/src/recyclerview/hooks/useInvertedWheelFix.ts
new file mode 100644
index 000000000..57fab81f3
--- /dev/null
+++ b/src/recyclerview/hooks/useInvertedWheelFix.ts
@@ -0,0 +1,13 @@
+import { RefObject } from "react";
+
+import { CompatScroller } from "../components/CompatScroller";
+
+/**
+ * Inverted lists only need a mouse-wheel direction fix on web. No-op native.
+ * See useInvertedWheelFix.web.ts.
+ */
+export function useInvertedWheelFix(
+  scrollViewRef: RefObject<CompatScroller>,
+  inverted: boolean | null | undefined,
+  horizontal: boolean | null | undefined
+): void {}
diff --git a/src/recyclerview/hooks/useInvertedWheelFix.web.ts b/src/recyclerview/hooks/useInvertedWheelFix.web.ts
new file mode 100644
index 000000000..fea18afd7
--- /dev/null
+++ b/src/recyclerview/hooks/useInvertedWheelFix.web.ts
@@ -0,0 +1,38 @@
+import { RefObject, useEffect } from "react";
+
+import { CompatScroller } from "../components/CompatScroller";
+
+/**
+ * On web an inverted list is flipped with transform: scaleY(-1) (scaleX(-1)
+ * when horizontal). The native mouse wheel is not flipped, so it scrolls the
+ * opposite way. Re-invert the wheel delta on the scroll node. Setting scrollTop
+ * fires the scroll event, so virtualization keeps working.
+ */
+export function useInvertedWheelFix(
+  scrollViewRef: RefObject<CompatScroller>,
+  inverted: boolean | null | undefined,
+  horizontal: boolean | null | undefined
+): void {
+  useEffect(() => {
+    if (!inverted) return;
+    const scrollNode = scrollViewRef.current?.getScrollableNode?.() as
+      | HTMLElement
+      | undefined;
+    if (!scrollNode?.addEventListener) return;
+
+    const onWheel = (event: WheelEvent) => {
+      if (horizontal) {
+        if (!event.deltaX) return;
+        event.preventDefault();
+        scrollNode.scrollLeft -= event.deltaX;
+      } else {
+        if (!event.deltaY) return;
+        event.preventDefault();
+        scrollNode.scrollTop -= event.deltaY;
+      }
+    };
+
+    scrollNode.addEventListener("wheel", onWheel, { passive: false });
+    return () => scrollNode.removeEventListener("wheel", onWheel);
+  }, [scrollViewRef, inverted, horizontal]);
+}
diff --git a/src/recyclerview/utils/measureLayout.web.ts b/src/recyclerview/utils/measureLayout.web.ts
index 05bebd332..3e3ac82f6 100644
--- a/src/recyclerview/utils/measureLayout.web.ts
+++ b/src/recyclerview/utils/measureLayout.web.ts
@@ -57,6 +57,21 @@ export function measureParentSize(view: Element): Size {
   };
 }
 
+/**
+ * Detects whether an element is flipped vertically via a scaleY(-1) transform
+ * (used by inverted lists on web). Reads the computed transform matrix.
+ */
+function isVerticallyFlipped(element: Element): boolean {
+  const transform = getComputedStyle(element as HTMLElement).transform;
+  if (!transform || transform === "none") return false;
+  const match = transform.match(/matrix(3d)?\(([^)]+)\)/);
+  if (!match) return false;
+  const values = match[2].split(",").map((value) => parseFloat(value));
+  // matrix(a,b,c,d,e,f) -> scaleY = d (index 3); matrix3d -> m22 (index 5)
+  const scaleY = match[1] ? values[5] : values[3];
+  return scaleY < 0;
+}
+
 /**
  * Measures the layout of child container of RecyclerView
  */
@@ -70,9 +85,16 @@ export function measureFirstChildLayout(
   // Get scroll offsets for child container (max 3 parents)
   const scrollOffsets = getScrollOffsets(childContainerView, parentView);
 
+  // When inverted on web the outer container is flipped with scaleY(-1), so
+  // getBoundingClientRect returns mirrored coordinates. Measure from the bottom
+  // edge in that case so firstItemOffset stays ~0 (matches non-inverted).
+  const y = isVerticallyFlipped(parentView)
+    ? parentRect.bottom - childRect.bottom + scrollOffsets.scrollY
+    : childRect.top - parentRect.top + scrollOffsets.scrollY;
+
   return {
     x: childRect.left - parentRect.left + scrollOffsets.scrollX,
-    y: childRect.top - parentRect.top + scrollOffsets.scrollY,
+    y,
     width: roundOffPixel(childRect.width),
     height: roundOffPixel(childRect.height),
   };