diff --git a/.github/workflows/automation.yml b/.github/workflows/automation.yml
index 497dad1c..7995cb90 100644
--- a/.github/workflows/automation.yml
+++ b/.github/workflows/automation.yml
@@ -1,6 +1,9 @@
 name: automation
 
 on:
+  push:
+    branches-ignore:
+        - "update/**"
   schedule:
     - cron: '3 2 1 * *'
 
@@ -10,12 +13,12 @@ jobs:
     timeout-minutes: 1200
 
     steps:
-    - name: Clone repository on current branch
-      run: |
-        rm -rf *
-        git clone https://github.com/$GITHUB_REPOSITORY --branch ${GITHUB_REF#refs/heads/} latest-ecModels
+      - name: Clone repository on current branch
+        run: |
+          rm -rf *
+          git clone https://github.com/$GITHUB_REPOSITORY --branch ${GITHUB_REF#refs/heads/} latest-ecModels
 
-    - name: Run the pipeline
-      run: |
-        cd latest-ecModels
-        python3 run.py ${GITHUB_REF#refs/heads/}
\ No newline at end of file
+      - name: Run the pipeline
+        run: |
+          cd latest-ecModels
+          python3 run.py ${GITHUB_REF#refs/heads/}
diff --git a/config.ini b/config.ini
index bfe377b2..5dafb5f2 100644
--- a/config.ini
+++ b/config.ini
@@ -1,6 +1,6 @@
 [BASE]
 url = https://github.com/SysBioChalmers/ecModels
-pull_request_target = master
+pull_request_target = main
 install_dir = /home/m/ecModels-dependencies/
 
 [MATLAB]
@@ -13,7 +13,7 @@ install_dir = cobratoolbox/
 
 [RAVEN]
 url = https://github.com/SysBioChalmers/RAVEN
-version = v2.4.1
+version = v2.6.2
 install_dir = RAVEN/
 
 [libSBML]
@@ -23,8 +23,8 @@ install_dir = libSBML/
 
 [Gurobi]
 url = https://www.gurobi.com/downloads/gurobi-software/
-version = v9.1.1
-install_dir = gurobi/
+version = v9.5.1
+install_dir = gurobi951/
 
 [GECKO]
 url = https://github.com/SysBioChalmers/GECKO
@@ -36,7 +36,7 @@ branch = master
 type = 'gem'
 url = https://github.com/SysBioChalmers/yeast-GEM
 download_url = 
-model_filename = /ModelFiles/mat/yeastGEM.mat
+model_filename = /model/yeast-GEM.mat
 mat_model = .model
 install_dir = yeast-GEM
 version = v8.3.1
@@ -46,7 +46,7 @@ database_tag = sce
 type = 'gem'
 url = https://github.com/SysBioChalmers/Yarrowia_lipolytica_W29-GEM
 download_url = 
-model_filename = /ModelFiles/mat/iYali.mat
+model_filename = /model/iYali.mat
 mat_model = .model
 install_dir = Yali-GEM
 version = v0
@@ -54,9 +54,9 @@ database_tag = yli
 
 [eciSM966]
 type = 'gem'
-url = https://github.com/SysBioChalmers/Kluyveromyces_marxianus-GEM
-download_url = 
-model_filename = /modelFiles/mat/Kluyveromyces_marxianus-GEM.mat
+url = 
+download_url = https://raw.githubusercontent.com/SysBioChalmers/Kluyveromyces_marxianus-GEM/master/modelFiles/mat/Kluyveromyces_marxianus-GEM.mat
+model_filename = /Kluyveromyces_marxianus-GEM.mat
 mat_model = .model
 install_dir = iSM966
 version = v0
@@ -69,7 +69,7 @@ download_url = http://bigg.ucsd.edu/static/models/iML1515.xml
 model_filename = /iML1515.xml
 mat_model = 
 install_dir = iML1515
-version = 2021-02-28-17-52
+version = 2022-07-03-23-05
 database_tag = eco
 
 [ecHumanGEM]
diff --git a/ecHumanGEM/scripts/changeMedia_batch.m b/ecHumanGEM/scripts/changeMedia_batch.m
index 1c2fecf4..2c614d97 100644
--- a/ecHumanGEM/scripts/changeMedia_batch.m
+++ b/ecHumanGEM/scripts/changeMedia_batch.m
@@ -116,7 +116,7 @@
     unusedMets = [];
     for i=1:length(mediaComps)
         %Get metabolite indx
-        metIndx = getIndexes(model,strcat(mediaComps{i},'[s]'),'metcomps');
+        metIndx = getIndexes(model,strcat(mediaComps{i},'[e]'),'metcomps');
         %Get rxns for metabolite
         metRxns = find(model.S(metIndx,:));
         %Get the uptake reaction for the metabolite
diff --git a/eciML1515/model/eciML1515.mat b/eciML1515/model/eciML1515.mat
index 5c03d1d0..87b2309d 100644
Binary files a/eciML1515/model/eciML1515.mat and b/eciML1515/model/eciML1515.mat differ
diff --git a/eciML1515/model/eciML1515.xml b/eciML1515/model/eciML1515.xml
index 22852b26..7faaf9d0 100644
--- a/eciML1515/model/eciML1515.xml
+++ b/eciML1515/model/eciML1515.xml
@@ -1,6 +1,6 @@
 <?xml version="1.0" encoding="UTF-8"?>
 <sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2" xmlns:groups="http://www.sbml.org/sbml/level3/version1/groups/version1" level="3" version="1" fbc:required="false" groups:required="false">
-  <model id="M_eciML1515_v2021__45__02__45__28__45__17__45__52" name="ecModel of iML1515" fbc:strict="true">
+  <model id="M_eciML1515_v2022__45__07__45__03__45__23__45__05" fbc:strict="true">
     <listOfUnitDefinitions>
       <unitDefinition id="mmol_per_gDW_per_hr">
         <listOfUnits>
@@ -38410,7 +38410,7 @@
       <reaction metaid="R_VALabcpp" id="R_VALabcpp" name="L-valine transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29805#2;29803#2;29806#2;29804#2</p>
+            <p>RheaID:29805#2; 29803#2; 29806#2; 29804#2</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -41402,7 +41402,7 @@
       <reaction metaid="R_CYSabc2pp" id="R_CYSabc2pp" name="L-cysteine export via ABC system (cytoplasm to periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:32796#2;32797#2;29783#1;29786#1;32798#2;29784#1;29785#1;32795#2</p>
+            <p>RheaID:32796#2; 32797#2; 29783#1; 29786#1; 32798#2; 29784#1; 29785#1; 32795#2</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -45581,7 +45581,7 @@
       <reaction metaid="R_LEUabcpp" id="R_LEUabcpp" name="L-leucine transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29810#1;29808#1;29809#1;29807#1</p>
+            <p>RheaID:29810#1; 29808#1; 29809#1; 29807#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -46637,7 +46637,7 @@
       <reaction metaid="R_ILEabcpp" id="R_ILEabcpp" name="L-isoleucine transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29820#1;29819#1;29821#1;29822#1</p>
+            <p>RheaID:29820#1; 29819#1; 29821#1; 29822#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -50100,7 +50100,7 @@
       <reaction metaid="R_ASO3t8pp" id="R_ASO3t8pp" name="Arsenite efflux via ATP hydrolysis (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:11351#1;11348#1;11350#1;11349#1</p>
+            <p>RheaID:11351#1; 11348#1; 11350#1; 11349#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -55626,7 +55626,7 @@
       <reaction metaid="R_GTHRDabc2pp" id="R_GTHRDabc2pp" name="Glutathione export via ABC system (cytoplasm to periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29788#1;29791#2;29790#1;29789#1;29787#1;29792#2;29794#2;29793#2</p>
+            <p>RheaID:29788#1; 29791#2; 29790#1; 29789#1; 29787#1; 29792#2; 29794#2; 29793#2</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -57482,7 +57482,7 @@
       <reaction metaid="R_FE3abcpp" id="R_FE3abcpp" name="Iron (III) transport via ABC system (periplasm to cytoplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:12335#1;12332#1;12334#1;12333#1</p>
+            <p>RheaID:12335#1; 12332#1; 12334#1; 12333#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
diff --git a/eciML1515/model/eciML1515_batch.mat b/eciML1515/model/eciML1515_batch.mat
index 4a5a4621..759d2a2c 100644
Binary files a/eciML1515/model/eciML1515_batch.mat and b/eciML1515/model/eciML1515_batch.mat differ
diff --git a/eciML1515/model/eciML1515_batch.xml b/eciML1515/model/eciML1515_batch.xml
index 52db7384..828f51e1 100644
--- a/eciML1515/model/eciML1515_batch.xml
+++ b/eciML1515/model/eciML1515_batch.xml
@@ -1,6 +1,6 @@
 <?xml version="1.0" encoding="UTF-8"?>
 <sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2" xmlns:groups="http://www.sbml.org/sbml/level3/version1/groups/version1" level="3" version="1" fbc:required="false" groups:required="false">
-  <model id="M_eciML1515_batch_v2021__45__02__45__28__45__17__45__52" name="ecModel_batch of iML1515" fbc:strict="true">
+  <model id="M_eciML1515_batch_v2022__45__07__45__03__45__23__45__05" fbc:strict="true">
     <listOfUnitDefinitions>
       <unitDefinition id="mmol_per_gDW_per_hr">
         <listOfUnits>
@@ -38412,7 +38412,7 @@
       <reaction metaid="R_VALabcpp" id="R_VALabcpp" name="L-valine transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB4N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29805#2;29803#2;29806#2;29804#2</p>
+            <p>RheaID:29805#2; 29803#2; 29806#2; 29804#2</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -41404,7 +41404,7 @@
       <reaction metaid="R_CYSabc2pp" id="R_CYSabc2pp" name="L-cysteine export via ABC system (cytoplasm to periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB4N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:32796#2;32797#2;29783#1;29786#1;32798#2;29784#1;29785#1;32795#2</p>
+            <p>RheaID:32796#2; 32797#2; 29783#1; 29786#1; 32798#2; 29784#1; 29785#1; 32795#2</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -45583,7 +45583,7 @@
       <reaction metaid="R_LEUabcpp" id="R_LEUabcpp" name="L-leucine transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB4N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29810#1;29808#1;29809#1;29807#1</p>
+            <p>RheaID:29810#1; 29808#1; 29809#1; 29807#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -46639,7 +46639,7 @@
       <reaction metaid="R_ILEabcpp" id="R_ILEabcpp" name="L-isoleucine transport via ABC system (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB4N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29820#1;29819#1;29821#1;29822#1</p>
+            <p>RheaID:29820#1; 29819#1; 29821#1; 29822#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -50102,7 +50102,7 @@
       <reaction metaid="R_ASO3t8pp" id="R_ASO3t8pp" name="Arsenite efflux via ATP hydrolysis (periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB4N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:11351#1;11348#1;11350#1;11349#1</p>
+            <p>RheaID:11351#1; 11348#1; 11350#1; 11349#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -55628,7 +55628,7 @@
       <reaction metaid="R_GTHRDabc2pp" id="R_GTHRDabc2pp" name="Glutathione export via ABC system (cytoplasm to periplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB4N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:29788#1;29791#2;29790#1;29789#1;29787#1;29792#2;29794#2;29793#2</p>
+            <p>RheaID:29788#1; 29791#2; 29790#1; 29789#1; 29787#1; 29792#2; 29794#2; 29793#2</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
@@ -57484,7 +57484,7 @@
       <reaction metaid="R_FE3abcpp" id="R_FE3abcpp" name="Iron (III) transport via ABC system (periplasm to cytoplasm)" reversible="false" fast="false" fbc:lowerFluxBound="FB1N0" fbc:upperFluxBound="FB4N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>RheaID:12335#1;12332#1;12334#1;12333#1</p>
+            <p>RheaID:12335#1; 12332#1; 12334#1; 12333#1</p>
           </body>
         </notes>
         <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
diff --git a/tools.py b/tools.py
index 0aa0cf45..fd2b1bdb 100644
--- a/tools.py
+++ b/tools.py
@@ -14,7 +14,7 @@
 DURL = 'download_url'
 IDIR = 'install_dir'
 SCRIPTSDIR = 'scripts'
-PIPELINE_BASE_BRANCH = 'master'
+PIPELINE_BASE_BRANCH = 'main'
 
 logging.basicConfig(level=logging.DEBUG)
 l = logging.getLogger(__name__)
@@ -67,8 +67,8 @@ def mat_model(self, gem):
     def pr_target(self):
         return self.config['BASE']['pull_request_target']
 
-    def git_clone(self, section, branch='master'):
-        cmd = sp.check_output(['git', 'clone', self.config[section][URL], '--depth', '1', '--branch', branch, self.install_dir(section)])
+    def git_clone(self, section, branch=PIPELINE_BASE_BRANCH):
+        cmd = sp.check_output(['hub', 'clone', self.config[section][URL], '--depth', '1', '--branch', branch, self.install_dir(section)])
         l.info(cmd.decode('utf-8'))
 
     def download(self, gem):
@@ -99,6 +99,8 @@ def git_add_and_pr(self, gem, matlab_output):
             cmd = sp.check_output(['git', 'commit', '-m', 'chore: update {} based on {}'.format(gem, self.version(gem))])
             l.info(cmd.decode('utf-8'))
             l.critical('Will push and create PR')
+            cmd = sp.check_output(['git', 'push'])
+            l.info(cmd.decode('utf-8'))
             # Create PR and also push
             pr_filename = "/tmp/githubpr"
             with open(pr_filename, "w") as f:
@@ -106,8 +108,7 @@ def git_add_and_pr(self, gem, matlab_output):
                 f.write("```matlab\n")
                 f.write(matlab_output)
                 f.write("\n```\n")
-            my_env = environ.copy()
-            cmd = sp.check_output(['hub', 'pull-request', '-F', pr_filename, '-b', self.pr_target(), '-p'], env=my_env)
+            cmd = sp.check_output(['gh', 'pr', 'create', '--body-file', pr_filename, '--base', self.pr_target(), '--fill'])
             l.info(cmd.decode('utf-8'))
         except sp.CalledProcessError:
             l.critical('While upgrading {} to {} no changes were detected'.format(gem, self.version(gem)))
@@ -137,7 +138,7 @@ def check_dependencies(self):
                     l.info('{} is still {}'.format(tool, tool_version))
         # Check COBRA, RAVEN, GECKO versions
         self.cleanup('GECKO')
-        self.git_clone('GECKO')
+        self.git_clone('GECKO', self.config['GECKO']['branch'])
         for tool in ['COBRA', 'RAVEN', 'GECKO']:
             tool_version = self.git_tag(tool)
             if tool_version != self.version(tool):