Motif Redundancy Resolution

[rodriguesk]

Hi, I have my SCENIC output and it shows FOXO1 is the TF for a specific gene set regulon. How does SCENIC know it is FOXO1 that controls the regulon genes and not some other TF that can bind the identical motif, for example FOXP1 or FOXP3? I understand how gene sets are formed (coexpression and have same motifs) but I do not understand how co-expressed genes are assigned to TF. How are binding motif redundancy among TFs handled? Does SCENIC handle motif redundancy or is there a heuristic? I ask because my data has many TFs that are expressed but all bind virtually identical motifs (like FOXP1, FOXP3, FOXO1, etc) yet only FOXO1 has a regulon in SCENIC output. Why is there not also a FOXP1 regulon gene set?