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956 lines (816 loc) · 34.8 KB
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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<title>PitNET</title>
<link rel="stylesheet" type="text/css" href="view.css" media="all">
<script type="text/javascript" src="view.js"></script>
<script>
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</script>
<style>
table, th, td {
border: 1px solid silver;
border-collapse: collapse;
padding: 4px;
}
</style>
</head>
<body>
<img id="top" src="top.png" alt="">
<div id="form_container">
<div class="form_description">
<h2>
<a href=".\cap\Cancer-Protocols-2025-03-Update\Endocrine Protocol Folder\Pituitary.NET_1.0.0.0.REL.CAPCP.pdf" target="_blank">
<div class="tooltip">
Pituitary Neuroendocrine Tumor
<span class="tooltiptext">click to access explanations in the original CAP template</span>
</div>
<a>
</h2>
</div>
<form>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Gross descriptions:</label></legend>
<p>
Useful information to be included from the case notes:<br>
1. Clinical history <br>
2. Functional status <br>
3. Tumor sizes from imaging<br>
4. Tumor extent or invasive growth from imaging<br>
</p>
<p>
<table border="1">
<col width="55%">
<tr>
<td>
<label class="description">- Procedure:</label>
</td>
<td>
<select class="element select large" ID="A01">
<option value=""></option>
<option value=" - Transsphenoidal pituitary tumor resection specimen">Transsphenoidal pituitary tumor resection specimen</option>
<option value=" - Transcranial pituitary tumor resection specimen">Transcranial pituitary tumor resection specimen</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor integrity:</label>
</td>
<td>
<select class="element select large" ID="A02">
<option value=""></option>
<option value=" - Intact">Intact</option>
<option value=" - Fragmented">Fragmented</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor size:</label>
</td>
<td>
<select class="element select large" ID="A03">
<option value=""></option>
<option value=" - Greatest dimension (mm): ">Greatest dimension (mm): </option>
<option value=" - Cannot be determined (explain): ">Cannot be determined (explain):</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Microscopic descriptions:</label></legend>
<p>
<label class="description">- Tumor histology: </label>
<textarea ID="A04" class="element textarea medium"></textarea>
</p>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description" > - Tumor Number: </label>
</td>
<td valign="top">
<select class="element select large" ID="A05">
<option value=""></option>
<option value="Single pituitary neuroendocrine tumor">Single pituitary neuroendocrine tumor</option>
<option value="Multiple pituitary neuroendocrine tumors">Multiple pituitary neuroendocrine tumors</option>
<option value="Other (specify):">Other (specify):</option>
</select>
For multiple pituitary neuroendocrine tumors, repeat the following <b>5</b> elements for each distinct pituitary neuroendocrine tumor:<br><br>
<b>
1. Tumor Types and Subtypes,<br>
2. Tumor Proliferative Activity, <br>
3. Histologically Confirmed Invasion, <br>
4. Histochemical Features, and <br>
5. Immunohistochemical Features</b>.<br>
<br>
This section can be repeated up to 10 times.
</td>
</tr>
<tr>
</tr>
<tr>
<td rowspan="5" valign="top">
<label class="description">1. Tumor Types and Subtypes:</label>
</td>
<tr>
<td>
<label class="description">TPIT-lineage pituitary neuroendocrine tumor (corticotroph tumor)</label>
<input class="element checkbox" type="checkbox" id="A06" value=" - TPIT-lineage pituitary neuroendocrine tumor (corticotroph tumor), Densely granulated corticotroph tumor"><label class="choice">Densely granulated corticotroph tumor</label>
<input class="element checkbox" type="checkbox" id="A07" value=" - TPIT-lineage pituitary neuroendocrine tumor (corticotroph tumor), Sparsely granulated corticotroph tumor"><label class="choice">Sparsely granulated corticotroph tumor</label>
<input class="element checkbox" type="checkbox" id="A08" value=" - TPIT-lineage pituitary neuroendocrine tumor (corticotroph tumor), Crooke cell tumor"><label class="choice">TPIT-lineage pituitary neuroendocrine tumor (corticotroph tumor), Crooke cell tumor</label>
<input class="element checkbox" type="checkbox" id="A09" value=" - TPIT-lineage pituitary neuroendocrine tumor (corticotroph tumor), Other (specify):"><label class="choice">TPIT-lineage pituitary neuroendocrine tumor (corticotroph tumor), Other (specify):</label>
</td>
</tr>
<tr>
<td>
<label class="description">PIT1-lineage pituitary neuroendocrine tumor</label>
<input class="element checkbox" type="checkbox" id="A10" value=" - PIT1-lineage pituitary neuroendocrine tumor, Somatotroph tumor, densely granulated"><label class="choice">Somatotroph tumor, densely granulated</label>
<input class="element checkbox" type="checkbox" id="A11" value=" - PIT1-lineage pituitary neuroendocrine tumor, Somatotroph tumor, sparsely granulated"><label class="choice">Somatotroph tumor, sparsely granulated</label>
<input class="element checkbox" type="checkbox" id="A12" value=" - PIT1-lineage pituitary neuroendocrine tumor, Lactotroph tumor, densely granulated"><label class="choice">Lactotroph tumor, densely granulated</label>
<input class="element checkbox" type="checkbox" id="A13" value=" - PIT1-lineage pituitary neuroendocrine tumor, Lactotroph tumor, sparsely granulated"><label class="choice">Lactotroph tumor, sparsely granulated</label>
<input class="element checkbox" type="checkbox" id="A14" value=" - PIT1-lineage pituitary neuroendocrine tumor, Thyrotroph tumor"><label class="choice">Thyrotroph tumor</label>
<input class="element checkbox" type="checkbox" id="A15" value=" - PIT1-lineage pituitary neuroendocrine tumor, Mammosomatotroph tumor"><label class="choice">Mammosomatotroph tumor</label>
<input class="element checkbox" type="checkbox" id="A16" value=" - PIT1-lineage pituitary neuroendocrine tumor, Mature PIT1-lineage plurihormonal tumor"><label class="choice">Mature PIT1-lineage plurihormonal tumor</label>
<input class="element checkbox" type="checkbox" id="A17" value=" - PIT1-lineage pituitary neuroendocrine tumor, Immature PIT1-lineage tumor"><label class="choice">Immature PIT1-lineage tumor</label>
<input class="element checkbox" type="checkbox" id="A18" value=" - PIT1-lineage pituitary neuroendocrine tumor, Acidophil stem cell tumor"><label class="choice">Acidophil stem cell tumor</label>
<input class="element checkbox" type="checkbox" id="A19" value=" - PIT1-lineage pituitary neuroendocrine tumor, Mixed somatotroph and lactotroph tumor (specify subtype)"><label class="choice">Mixed somatotroph and lactotroph tumor (specify subtype)</label>
<input class="element checkbox" type="checkbox" id="A20" value=" - PIT1-lineage pituitary neuroendocrine tumor, Other (specify):"><label class="choice">Other (specify):</label>
</td>
</tr>
<tr>
<td >
<label class="description">SF1-lineage pituitary neuroendocrine tumor</label>
<input class="element checkbox" type="checkbox" id="A21" value=" - SF1-lineage pituitary neuroendocrine tumor, Gonadotroph tumor"><label class="choice">Gonadotroph tumor</label>
<input class="element checkbox" type="checkbox" id="A22" value=" - SF1-lineage pituitary neuroendocrine tumor, Other (specify):"><label class="choice">Other (specify):</label>
</td>
</tr>
<tr>
<td>
<label class="description">Pituitary neuroendocrine tumor of no distinct cell lineage</label>
<input class="element checkbox" type="checkbox" id="A23" value=" - Pituitary neuroendocrine tumor of no distinct cell lineage, Null cell tumor"><label class="choice">Null cell tumor</label>
<input class="element checkbox" type="checkbox" id="A24" value=" - Pituitary neuroendocrine tumor of no distinct cell lineage, Unusual plurihormonal (multilineage) pituitary neuroendocrine tumors (specify)"><label class="choice">Unusual plurihormonal (multilineage) pituitary neuroendocrine tumors (specify)</label>
<input class="element checkbox" type="checkbox" id="A25" value=" - Pituitary neuroendocrine tumor, NOS"><label class="choice">Pituitary neuroendocrine tumor, NOS</label>
<input class="element checkbox" type="checkbox" id="A26" value=" - Other (specify):"><label class="choice">Other (specify):</label>
</td>
</tr>
<tr>
<td rowspan="3" valign="top">
<label class="description">2. Tumor Proliferative Activity:</label>
</td>
</tr>
<tr>
<td >
<label class=""><b>- <a href=".\cap\LaRosa2023.pdf" target="_blank">Ki-67 Labeling Index</a>:</b></label>
<input type="text" class="element text Medium" ID="A27" size="15">
<p>Selecting multiple small hot spots (at least 500 tumor cells) from different hot spot regions of the tumor rather than a single larger area of the same tumor are recommended.</p>
</td>
</tr>
<tr>
<td >
<label class="">+ Mitotic Count (per 2 mm<sup>2</sup>):</label>
<input type="text" class="element text Medium" ID="A28" size="15">
<p>Using 22 mm eyepiece at 40x objective, count active proliferative areas for 42 fields (equals 10 mm<sup>2</sup>), divide by 5 to get mitotic count for 2 mm<sup>2</sup></p>
</td>
</tr>
<tr>
<td>
<label class="description">3. Histologically Confirmed Invasion: </label>
</td>
<td>
<select class="element select large" ID="A29">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present (specify):">Present (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td rowspan="4" valign="top">
<label class="">4. + Histochemical stains:</label>
</td>
<tr>
<tr>
<td align="right">
<label class="">+ Reticulin Histochemistry</label>
<select class="element select medium" ID="A30">
<option value=""></option>
<option value="Not performed">Not performed</option>
<option value="Disrupted">Disrupted</option>
<option value="Expanded acini">Expanded acini</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ PAS Histochemistry</label>
<select class="element select medium" ID="A31">
<option value=""></option>
<option value="Not performed">Not performed</option>
<option value="Positive">Positive</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td rowspan="16" valign="top">
<label class="description">5. Immunohistochemical studies</label>
</td>
</tr>
<tr>
<td align="right">
<label class="">- <b>TPIT</b></label>
<select class="element select medium" ID="A32">
<option value=""></option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">- <b>PIT1</b></label>
<select class="element select medium" ID="A33">
<option value=""></option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">- <b>SF1</b></label>
<select class="element select medium" ID="A34">
<option value=""></option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ GATA3</label>
<select class="element select medium" ID="A35">
<option value=""></option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ ER-alpha</label>
<select class="element select medium" ID="A36">
<option value=""></option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ alpha-subunit</label>
<select class="element select medium" ID="A37">
<option value=""></option>
<option value="Not available">Not available</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">- <b>ACTH (TPIT-tumors)</b></label>
<select class="element select medium" ID="A38">
<option value=""></option>
<option value="Not applicable">Not applicable</option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">- <b>GH (PIT1-tumors)</b></label>
<select class="element select medium" ID="A39">
<option value=""></option>
<option value="Not applicable">Not applicable</option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">- <b>PRL (PIT1-tumors)</b></label>
<select class="element select medium" ID="A40">
<option value=""></option>
<option value="Not applicable">Not applicable</option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">- <b>beta-TSH (PIT1-tumors)</b></label>
<select class="element select medium" ID="A41">
<option value=""></option>
<option value="Not applicable">Not applicable</option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Not available">Not available</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ beta-FSH</label>
<select class="element select medium" ID="A42">
<option value=""></option>
<option value="Positive, diffuse">Positive, diffuse</option>
<option value="Positive, focal">Positive, focal</option>
<option value="Negative">Negative</option>
<option value="Not available">Not available</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ p27</label>
<select class="element select medium" ID="A43">
<option value=""></option>
<option value="Not available">Not available</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ ATRX</label>
<select class="element select medium" ID="A44">
<option value=""></option>
<option value="Intact">Intact</option>
<option value="Loss">Loss</option>
<option value="Not available">Not available</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td align="right">
<label class="">+ p53</label>
<select class="element select medium" ID="A45">
<option value=""></option>
<option value="Abnormal">Abnormal</option>
<option value="Wild-type">Wild-type</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="">- <b>Low Molecular Weight Keratins</b></label>
<select class="element select small" ID="A46">
<option value=""></option>
<option value="Not applicable">Not applicable</option>
<option value="Positive">Positive</option>
<option value="Negative">Negative</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Cannot be determined">Cannot be determined</option>
</select><br><br>
Extent of Reactivity:
<select class="element select medium" ID="A47">
<option value=""></option>
<option value="Diffuse">Diffuse</option>
<option value="Focal (non-diffuse)">Focal (non-diffuse)</option>
<option value="Other (specify):">Other (specify):</option>
</select><br><br>
Pattern of Reactivity:
<input class="element checkbox" type="checkbox" id="A48" value=" - Fibrous bodies (accounting for greater than 70% of the tumor)"><label class="choice">Fibrous bodies (accounting for greater than 70% of the tumor)</label>
<input class="element checkbox" type="checkbox" id="A49" value=" - Fibrous bodies (variable / scattered, accounting for less than 70% of the tumor)"><label class="choice">Fibrous bodies (variable / scattered, accounting for less than 70% of the tumor)</label>
<input class="element checkbox" type="checkbox" id="A50" value=" - Perinuclear cytoplasmic"><label class="choice">Perinuclear cytoplasmic</label>
<input class="element checkbox" type="checkbox" id="A51" value=" - Diffuse dense cytoplasmic"><label class="choice">Diffuse dense cytoplasmic</label>
<input class="element checkbox" type="checkbox" id="A52" value=" - Ring-like cytoplasmic"><label class="choice">Ring-like cytoplasmic</label>
<input class="element checkbox" type="checkbox" id="A53" value=" - Membranous"><label class="choice">Membranous</label>
<input class="element checkbox" type="checkbox" id="A54" value=" - Other (specify):"><label class="choice">Other (specify):</label>
</td>
</tr>
</table>
</p>
</fieldset>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description">Metastasis: </label></legend>
<input class="element checkbox" type="checkbox" id="A55" value=" - Not applicable"><label class="choice" >Not applicable</label>
<input class="element checkbox" type="checkbox" id="A56" value=" - Not identified"><label class="choice" >Not identified</label>
<input class="element checkbox" type="checkbox" id="A57" value=" - Cerebrospinal (specify site(s)):"><label class="choice" >Cerebrospinal (specify site(s)):</label>
<input class="element checkbox" type="checkbox" id="A58" value=" - Bone (specify):"><label class="choice" >Bone (specify):</label>
<input class="element checkbox" type="checkbox" id="A59" value=" - Liver (specify):"><label class="choice" >Liver (specify):</label>
<input class="element checkbox" type="checkbox" id="A60" value=" - Other (specify):"><label class="choice" >Other (specify):</label>
<input class="element checkbox" type="checkbox" id="A61" value=" - Cannot be determined: "><label class="choice" >Cannot be determined: </label>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description">Non-tumorous Pituitary Site(s): </label></legend>
<p>
<input class="element checkbox" type="checkbox" id="A62" value=" - Not applicable"><label class="choice" >Not applicable</label>
<input class="element checkbox" type="checkbox" id="A63" value=" - Not identified"><label class="choice" >Not identified</label>
<input class="element checkbox" type="checkbox" id="A64" value=" - Adenohypophysis identified"><label class="choice">Adenohypophysis identified</label>
<input class="element checkbox" type="checkbox" id="A65" value=" - Adenohypophysis identified, Crooke’s Hyaline Change of the Non-tumorous Corticotrophs (required for all corticotroph tumors)"><label class="choice" >Adenohypophysis identified, Crooke’s Hyaline Change of the Non-tumorous Corticotrophs (required for all corticotroph tumors)</label>
<input class="element checkbox" type="checkbox" id="A66" value=" - Adenohypophysis identified, + Pituitary Hyperplasia"><label class="choice" >Adenohypophysis identified, + Pituitary Hyperplasia</label>
<input class="element checkbox" type="checkbox" id="A67" value=" - Neurohypophysis identified"><label class="choice" >Neurohypophysis identified</label>
<input class="element checkbox" type="checkbox" id="A68" value=" - Cannot be determined (explain):"><label class="choice" >Cannot be determined (explain):</label>
<input class="element checkbox" type="checkbox" id="A69" value=" - Other (specify):"><label class="choice" >Other (specify):</label>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label > + Additional pathologic findings: </label></legend>
<p>
<input class="element checkbox" type="checkbox" id="A70" value=" - Not applicable"><label class="choice" >Not applicable</label>
<input class="element checkbox" type="checkbox" id="A71" value=" - Not identified"><label class="choice" >Not identified</label>
<input class="element checkbox" type="checkbox" id="A72" value=" - Hypophysitis (specify):"><label class="choice">Hypophysitis (specify):</label>
<input class="element checkbox" type="checkbox" id="A73" value=" - Craniopharyngioma (specify type):"><label class="choice" >Craniopharyngioma (specify type):</label>
<input class="element checkbox" type="checkbox" id="A74" value=" - Rathke’s cleft cyst (specify):"><label class="choice" >Rathke’s cleft cyst (specify):</label>
<input class="element checkbox" type="checkbox" id="A75" value=" - Acute hemorrhagic necrosis (apoplexy)"><label class="choice" >Acute hemorrhagic necrosis (apoplexy)</label>
<input class="element checkbox" type="checkbox" id="A76" value=" - Other (specify):"><label class="choice" >Other (specify):</label>
</p>
</fieldset>
</p>
<p>
<label class="description">- Additional notes:</label>
<textarea ID="A77" class = "element textarea medium" style="border-color:Grey;"></textarea>
</p>
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Last upated on 21-Jun-2025,<br>
based on
<a href="https://www.cap.org/protocols-and-guidelines/cancer-reporting-tools/cancer-protocol-templates" target="_blank">US CAP cancer protocol templates</a>.<br>
Pituitary Neuroendocrine Tumor 1.0.0.0 Mar-2025.<br>
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Anatomical Pathology Division, Queen Mary Hospital, Hong Kong.
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