diff --git a/src/index.ts b/src/index.ts
index 35f4aed..3216043 100644
--- a/src/index.ts
+++ b/src/index.ts
@@ -6,6 +6,8 @@ import esbuildPlugin from 'node-stdlib-browser/helpers/esbuild/plugin'
 import type { Plugin } from 'vite'
 import { compareModuleNames, isEnabled, isNodeProtocolImport, toRegExp, withoutNodeProtocol } from './utils'
 
+type TransformHook = Extract<Plugin['transform'], Function>
+
 export type BuildTarget = 'build' | 'dev'
 export type BooleanOrBuildTarget = boolean | BuildTarget
 export type ModuleName = keyof typeof stdLibBrowser
@@ -130,7 +132,7 @@ const globalShimBanners = {
  * })
  * ```
  */
-export const nodePolyfills = (options: PolyfillOptions = {}): Plugin => {
+export const nodePolyfills = (options: PolyfillOptions = {}): Plugin[] => {
   const optionsResolved: PolyfillOptionsResolved = {
     include: [],
     exclude: [],
@@ -199,7 +201,23 @@ export const nodePolyfills = (options: PolyfillOptions = {}): Plugin => {
     ``,
   ].join('\n')
 
-  return {
+  let rawInjectPlugin: Plugin | false | undefined
+  function transform(this: ThisParameterType<TransformHook>, code: string, id: string, opts: Parameters<TransformHook>[2]) {
+    if (rawInjectPlugin === undefined) {
+      throw new Error('transform called before inject plugin initialization')
+    }
+    if (rawInjectPlugin === false) {
+      return
+    }
+    return (rawInjectPlugin.transform as TransformHook).call(this, code, id, opts)
+  }
+  const injectPlugin: Plugin = {
+    name: 'vite-plugin-node-polyfills:inject',
+    enforce: 'post',
+    transform,
+  }
+
+  const plugin: Plugin = {
     name: 'vite-plugin-node-polyfills',
     config(config, env) {
       const isDev = env.command === 'serve'
@@ -220,6 +238,17 @@ export const nodePolyfills = (options: PolyfillOptions = {}): Plugin => {
         ...(isEnabled(optionsResolved.globals.process, 'build') ? { process: 'vite-plugin-node-polyfills/shims/process' } : {}),
       }
 
+      const isNativeInjectAvailable = env.command === 'build' && isRolldownVite
+      rawInjectPlugin = (Object.keys(shimsToInject).length > 0 && !isNativeInjectAvailable) ? inject(shimsToInject) as Plugin : false
+      if (rawInjectPlugin === false) {
+        delete injectPlugin.transform
+      } else {
+        // hook filters are only supported in Vite 6.3.0+
+        (transform as any).filter = {
+          code: new RegExp(Object.keys(shimsToInject).join('|')),
+        }
+      }
+
       return {
         build: {
           rollupOptions: {
@@ -232,17 +261,11 @@ export const nodePolyfills = (options: PolyfillOptions = {}): Plugin => {
                 rollupWarn(warning)
               })
             },
-            ...Object.keys(shimsToInject).length > 0
-              ? isRolldownVite
-                ? { transform: { inject: shimsToInject } }
-                : { plugins: [inject(shimsToInject)] }
+            ...(Object.keys(shimsToInject).length > 0 && isRolldownVite)
+              ? { transform: { inject: shimsToInject } }
               : {},
           },
         },
-        esbuild: {
-          // In dev, the global polyfills need to be injected as a banner in order for isolated scripts (such as Vue SFCs) to have access to them.
-          banner: isDev ? globalShimsBanner : undefined,
-        },
         optimizeDeps: {
           exclude: [
             ...globalShimPaths,
@@ -308,4 +331,8 @@ export const nodePolyfills = (options: PolyfillOptions = {}): Plugin => {
       }
     },
   }
+  return [
+    injectPlugin,
+    plugin,
+  ]
 }
diff --git a/test/integration/global-references/index.test.ts b/test/integration/global-references/index.test.ts
index 8bace33..dc139d4 100644
--- a/test/integration/global-references/index.test.ts
+++ b/test/integration/global-references/index.test.ts
@@ -7,12 +7,7 @@ describe('import globals', () => {
       const result = await transformDev(`Buffer.from('test')`)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
+        import { default as Buffer } from "/shims/buffer/dist/index.js";
 
         Buffer.from("test");
       `))
@@ -28,8 +23,7 @@ describe('import globals', () => {
       })
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
+        import { default as Buffer } from "/shims/buffer/dist/index.js";
 
         Buffer.from("test");
       `))
@@ -41,12 +35,7 @@ describe('import globals', () => {
       const result = await transformDev(`console.log(global)`)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
+        import { default as global } from "/shims/global/dist/index.js";
 
         console.log(global);
       `))
@@ -62,8 +51,7 @@ describe('import globals', () => {
       })
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
+        import { default as global } from "/shims/global/dist/index.js";
 
         console.log(global);
       `))
@@ -75,12 +63,7 @@ describe('import globals', () => {
       const result = await transformDev(`console.log(process)`)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
+        import { default as process } from "/shims/process/dist/index.js";
 
         console.log(process);
       `))
@@ -96,8 +79,7 @@ describe('import globals', () => {
       })
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
+        import { default as process } from "/shims/process/dist/index.js";
 
         console.log(process);
       `))
diff --git a/test/integration/import-globals/index.test.ts b/test/integration/import-globals/index.test.ts
index 90ef455..7fa8173 100644
--- a/test/integration/import-globals/index.test.ts
+++ b/test/integration/import-globals/index.test.ts
@@ -10,13 +10,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import Buffer from "/shims/buffer/dist/index.js";
         console.log(Buffer);
       `))
@@ -29,13 +22,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import Buffer from "/shims/buffer/dist/index.js";
         console.log(Buffer);
       `))
@@ -48,13 +34,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import Buffer from "/shims/buffer/dist/index.js";
         console.log(Buffer);
       `))
@@ -67,13 +46,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import Buffer from "/shims/buffer/dist/index.js";
         console.log(Buffer);
       `))
@@ -88,13 +60,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import process from "/shims/process/dist/index.js";
         console.log(process);
       `))
@@ -107,13 +72,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import process from "/shims/process/dist/index.js";
         console.log(process);
       `))
@@ -126,13 +84,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import process from "/shims/process/dist/index.js";
         console.log(process);
       `))
@@ -145,13 +96,6 @@ describe('import globals', () => {
       `)
 
       expect(result?.code).toEqual(formatWhitespace(`
-        import __buffer_polyfill from "/shims/buffer/dist/index.js"
-        globalThis.Buffer = globalThis.Buffer || __buffer_polyfill
-        import __global_polyfill from "/shims/global/dist/index.js"
-        globalThis.global = globalThis.global || __global_polyfill
-        import __process_polyfill from "/shims/process/dist/index.js"
-        globalThis.process = globalThis.process || __process_polyfill
-
         import process from "/shims/process/dist/index.js";
         console.log(process);
       `))