diff --git a/src/coreclr/debug/daccess/dacdbiimplstackwalk.cpp b/src/coreclr/debug/daccess/dacdbiimplstackwalk.cpp
index dc13cf59a7f006..02bb3dcd3f5f57 100644
--- a/src/coreclr/debug/daccess/dacdbiimplstackwalk.cpp
+++ b/src/coreclr/debug/daccess/dacdbiimplstackwalk.cpp
@@ -476,7 +476,16 @@ ULONG32 DacDbiInterfaceImpl::GetCountOfInternalFrames(VMPTR_Thread vmThread)
             InlinedCallFrame *pInlinedCallFrame = dac_cast<PTR_InlinedCallFrame>(pFrame);
             PTR_PInvokeMethodDesc pMD = pInlinedCallFrame->m_Datum;
             TADDR datum = dac_cast<TADDR>(pMD);
+#ifdef TARGET_64BIT
+            // On 64-bit platforms, an unmanaged calli target is encoded as (target << 1) | 1,
+            // so bit 0 must be checked first to distinguish it from a MethodDesc pointer with
+            // the InlinedCallFrameMarker::ExceptionHandlingHelper bit set. Otherwise, an odd
+            // calli target's shifted-in low bit can be misread as the marker.
+            if ((datum & 0x1) == 0 &&
+                (datum & (TADDR)InlinedCallFrameMarker::Mask) == (TADDR)InlinedCallFrameMarker::ExceptionHandlingHelper)
+#else
             if ((datum & (TADDR)InlinedCallFrameMarker::Mask) == (TADDR)InlinedCallFrameMarker::ExceptionHandlingHelper)
+#endif // TARGET_64BIT
             {
                 pFrame = pFrame->Next();
                 continue;
@@ -529,7 +538,16 @@ void DacDbiInterfaceImpl::EnumerateInternalFrames(VMPTR_Thread
             InlinedCallFrame *pInlinedCallFrame = dac_cast<PTR_InlinedCallFrame>(pFrame);
             PTR_PInvokeMethodDesc pMD = pInlinedCallFrame->m_Datum;
             TADDR datum = dac_cast<TADDR>(pMD);
+#ifdef TARGET_64BIT
+            // On 64-bit platforms, an unmanaged calli target is encoded as (target << 1) | 1,
+            // so bit 0 must be checked first to distinguish it from a MethodDesc pointer with
+            // the InlinedCallFrameMarker::ExceptionHandlingHelper bit set. Otherwise, an odd
+            // calli target's shifted-in low bit can be misread as the marker.
+            if ((datum & 0x1) == 0 &&
+                (datum & (TADDR)InlinedCallFrameMarker::Mask) == (TADDR)InlinedCallFrameMarker::ExceptionHandlingHelper)
+#else
             if ((datum & (TADDR)InlinedCallFrameMarker::Mask) == (TADDR)InlinedCallFrameMarker::ExceptionHandlingHelper)
+#endif // TARGET_64BIT
             {
                 pFrame = pFrame->Next();
                 continue;