diff --git a/lib/elixir/src/elixir_expand.erl b/lib/elixir/src/elixir_expand.erl
index 97e72d52da8..e52bceb3827 100644
--- a/lib/elixir/src/elixir_expand.erl
+++ b/lib/elixir/src/elixir_expand.erl
@@ -266,6 +266,9 @@ expand({quote, Meta, [Opts, Do]}, S, E) when is_list(Do) ->
   Unquote = proplists:get_value(unquote, EOpts, DefaultUnquote),
   Generated = proplists:get_value(generated, EOpts, false),
 
+  (map_get(context, E) /= nil) andalso Unquote andalso elixir_quote:has_unquotes(Exprs) andalso
+    file_error(Meta, E, ?MODULE, quote_in_pattern_with_unquote),
+
   {Q, QContext, QPrelude} = elixir_quote:build(Meta, Line, File, Context, Unquote, Generated, ET),
   {EPrelude, SP, EP} = expand(QPrelude, ST, ET),
   {EContext, SC, EC} = expand(QContext, SP, EP),
@@ -1216,6 +1219,8 @@ format_error({expected_compile_time_module, Kind, GivenTerm}) ->
 format_error({unquote_outside_quote, Unquote}) ->
   %% Unquote can be "unquote" or "unquote_splicing".
   io_lib:format("~p called outside quote", [Unquote]);
+format_error(quote_in_pattern_with_unquote) ->
+  "unquote is not allowed when quote is used inside a pattern or guard";
 format_error({invalid_bind_quoted_for_quote, BQ}) ->
   io_lib:format("invalid :bind_quoted for quote, expected a keyword list of variable names, got: ~ts",
                 ['Elixir.Macro':to_string(BQ)]);
diff --git a/lib/elixir/test/elixir/kernel/errors_test.exs b/lib/elixir/test/elixir/kernel/errors_test.exs
index 2c1dc605ae7..06d1ed68e03 100644
--- a/lib/elixir/test/elixir/kernel/errors_test.exs
+++ b/lib/elixir/test/elixir/kernel/errors_test.exs
@@ -456,6 +456,21 @@ defmodule Kernel.ErrorsTest do
                       """
   end
 
+  test "invalid unquote when quote/1 is in a pattern" do
+    assert_compile_error(
+      ["unquote is not allowed when quote is used inside a pattern or guard"],
+      ~c"""
+      defmodule Kernel.ErrorsTest.InvalidUnquoteInQuotePattern do
+        def my_fun(ast) do
+          case ast do
+            quote(do: foo(unquote(x))) -> x
+          end
+        end
+      end
+      """
+    )
+  end
+
   test "invalid attribute" do
     msg = ~r"cannot inject attribute @foo into function/macro because cannot escape "