Can I using blood proteomics data to impute?

[YundanLiao]

Hi,

I am currently working on a project where I plan to use BrainGENIE to impute brain gene expression from blood proteomics data. However, I noticed that your model was developed using RNA-seq data.

Given the differences between RNA-seq and proteomics data, I am curious about the potential implications of this for my project. Could you provide some insights into whether BrainGENIE would be suitable for this purpose, or if there might be any considerations or adjustments needed?

Thank you for your time and assistance.

Best regards,
Yundan Liao

[hessJ]

Interesting project! On average, the correlation between RNA and protein levels are not very strong, so I would suspect that BrainGENIE would not provide reliable results in this use case. Good luck on your project!