diff --git a/loopy/target/c/codegen/expression.py b/loopy/target/c/codegen/expression.py
index 7bbee772e..f32dd14e3 100644
--- a/loopy/target/c/codegen/expression.py
+++ b/loopy/target/c/codegen/expression.py
@@ -464,8 +464,59 @@ def map_if(self, expr: p.If, type_context: TypeContext):
                 self.rec(expr.else_, type_context, result_type),
                 )
 
+    def _is_mixed_sign_integer_pair(
+                self,
+                dtype1: LoopyType,
+                dtype2: LoopyType,
+            ) -> bool:
+        """Return True if *dtype1* and *dtype2* are integers of opposite
+        signedness (one signed, one unsigned)."""
+        return (
+            isinstance(dtype1, NumpyType)
+            and isinstance(dtype2, NumpyType)
+            and dtype1.is_integral()
+            and dtype2.is_integral()
+            and dtype1.numpy_dtype.kind != dtype2.numpy_dtype.kind
+        )
+
+    def _common_signed_dtype(
+                self,
+                dtype1: np.dtype,
+                dtype2: np.dtype,
+            ) -> NumpyType:
+        """Return the narrowest signed integer dtype that can hold all values
+        of both *dtype1* and *dtype2* (which must be integer dtypes).
+
+        Used to pick a common cast target when comparing or combining
+        mixed-sign integers, so that C's implicit unsigned-promotion rule
+        cannot give wrong results.
+        """
+        common = np.result_type(dtype1, dtype2)
+        if common.kind == "i":
+            return NumpyType(common)
+        # int64 vs uint64: numpy says float64; fall back to int64 (the widest
+        # standard signed type) and accept that uint64 values above INT64_MAX
+        # will not be represented correctly.
+        return NumpyType(np.dtype(np.int64))
+
     @override
     def map_comparison(self, expr: p.Comparison, type_context: TypeContext):
+        left_dtype = self.infer_type(cast("ArithmeticExpression", expr.left))
+        right_dtype = self.infer_type(cast("ArithmeticExpression", expr.right))
+
+        if self._is_mixed_sign_integer_pair(left_dtype, right_dtype):
+            # C would silently convert the signed operand to unsigned (giving
+            # wrong results for negative values).  Cast both to a common
+            # signed type to get Python-like semantics.
+            assert isinstance(left_dtype, NumpyType)
+            assert isinstance(right_dtype, NumpyType)
+            common_type = self._common_signed_dtype(
+                left_dtype.numpy_dtype, right_dtype.numpy_dtype)
+            return type(expr)(
+                self.rec(expr.left, "i", common_type),
+                expr.operator,
+                self.rec(expr.right, "i", common_type))
+
         inner_type_context = dtype_to_type_context(
                 self.kernel.target,
                 self.infer_type(
@@ -477,6 +528,63 @@ def map_comparison(self, expr: p.Comparison, type_context: TypeContext):
                     expr.operator,
                     self.rec(expr.right, inner_type_context))
 
+    @override
+    def map_sum(self, expr: p.Sum, type_context: TypeContext):
+        result_dtype = self.infer_type(expr)
+
+        if (isinstance(result_dtype, NumpyType)
+                and result_dtype.numpy_dtype.kind == "i"
+                and result_dtype.is_integral()):
+            # If any child is an unsigned integer, cast it to the signed
+            # result type before addition.  Without this, C's usual arithmetic
+            # conversions would let the unsigned operand "win" and silently
+            # turn the computation into unsigned arithmetic.
+            new_children = []
+            modified = False
+            for child in expr.children:
+                child_dtype = self.infer_type(
+                    cast("ArithmeticExpression", child))
+                if (isinstance(child_dtype, NumpyType)
+                        and child_dtype.numpy_dtype.kind == "u"):
+                    new_children.append(
+                        self.rec(child, type_context, result_dtype))
+                    modified = True
+                else:
+                    new_children.append(self.rec(child, type_context))
+            if modified:
+                return type(expr)(tuple(new_children))
+
+        return type(expr)(tuple(
+            self.rec(child, type_context) for child in expr.children))
+
+    @override
+    def map_product(self, expr: p.Product, type_context: TypeContext):
+        result_dtype = self.infer_type(expr)
+
+        if (isinstance(result_dtype, NumpyType)
+                and result_dtype.numpy_dtype.kind == "i"
+                and result_dtype.is_integral()):
+            # Same rationale as map_sum: cast unsigned factors to the signed
+            # result type so the C multiplication is performed in signed
+            # arithmetic.
+            new_children = []
+            modified = False
+            for child in expr.children:
+                child_dtype = self.infer_type(
+                    cast("ArithmeticExpression", child))
+                if (isinstance(child_dtype, NumpyType)
+                        and child_dtype.numpy_dtype.kind == "u"):
+                    new_children.append(
+                        self.rec(child, type_context, result_dtype))
+                    modified = True
+                else:
+                    new_children.append(self.rec(child, type_context))
+            if modified:
+                return type(expr)(tuple(new_children))
+
+        return type(expr)(tuple(
+            self.rec(child, type_context) for child in expr.children))
+
     @override
     def map_type_cast(self,
                 expr: TypeCast,
diff --git a/test/test_c_execution.py b/test/test_c_execution.py
index 255a78c71..07f554530 100644
--- a/test/test_c_execution.py
+++ b/test/test_c_execution.py
@@ -366,6 +366,133 @@ def test_scalar_global_args():
     assert out == (n*(n-1)/2)  # noqa: RUF069
 
 
+@pytest.mark.parametrize("signed_dtype,unsigned_dtype", [
+    (np.int8, np.uint8),
+    (np.int16, np.uint16),
+    (np.int32, np.uint32),
+    (np.int64, np.uint64),
+])
+def test_mixed_sign_comparison(signed_dtype, unsigned_dtype):
+    """Mixed-sign comparisons must follow Python semantics (not C's
+    implicit unsigned-promotion rule).  The classic C footgun is:
+
+        int x = -1; unsigned int y = 1;
+        if (x < y) { ... }  // NOT taken — x becomes UINT_MAX
+
+    Loopy should generate explicit casts so the branch IS taken.
+    """
+    t_unit = lp.make_kernel(
+        "{:}",
+        """
+        lt_result   = if(sv < uv, 1, 0)
+        le_result   = if(sv <= uv, 1, 0)
+        gt_result   = if(sv > uv, 1, 0)
+        ge_result   = if(sv >= uv, 1, 0)
+        eq_result   = if(sv == uv, 1, 0)
+        ne_result   = if(sv != uv, 1, 0)
+        """,
+        [
+            lp.ValueArg("sv", signed_dtype),
+            lp.ValueArg("uv", unsigned_dtype),
+            lp.GlobalArg("lt_result, le_result, gt_result, "
+                         "ge_result, eq_result, ne_result",
+                         np.int32, shape=lp.auto),
+        ],
+        target=lp.ExecutableCTarget(),
+    )
+    t_unit = lp.set_options(t_unit, return_dict=True)
+
+    # --- sv = -1, uv = 1 -------------------------------------------------------
+    # Python:  -1 < 1  → True, -1 <= 1 → True, -1 > 1 → False,
+    #          -1 >= 1 → False, -1 == 1 → False, -1 != 1 → True
+    sv = signed_dtype(-1)
+    uv = unsigned_dtype(1)
+    _evt, out = t_unit(sv=sv, uv=uv)
+    assert out["lt_result"][()] == 1, f"{sv} < {uv} should be True"
+    assert out["le_result"][()] == 1, f"{sv} <= {uv} should be True"
+    assert out["gt_result"][()] == 0, f"{sv} > {uv} should be False"
+    assert out["ge_result"][()] == 0, f"{sv} >= {uv} should be False"
+    assert out["eq_result"][()] == 0, f"{sv} == {uv} should be False"
+    assert out["ne_result"][()] == 1, f"{sv} != {uv} should be True"
+
+    # --- sv = 1, uv = 1 --------------------------------------------------------
+    sv = signed_dtype(1)
+    uv = unsigned_dtype(1)
+    _evt, out = t_unit(sv=sv, uv=uv)
+    assert out["lt_result"][()] == 0, f"{sv} < {uv} should be False"
+    assert out["le_result"][()] == 1, f"{sv} <= {uv} should be True"
+    assert out["gt_result"][()] == 0, f"{sv} > {uv} should be False"
+    assert out["ge_result"][()] == 1, f"{sv} >= {uv} should be True"
+    assert out["eq_result"][()] == 1, f"{sv} == {uv} should be True"
+    assert out["ne_result"][()] == 0, f"{sv} != {uv} should be False"
+
+    # --- sv = 2, uv = 1 --------------------------------------------------------
+    sv = signed_dtype(2)
+    uv = unsigned_dtype(1)
+    _evt, out = t_unit(sv=sv, uv=uv)
+    assert out["lt_result"][()] == 0, f"{sv} < {uv} should be False"
+    assert out["le_result"][()] == 0, f"{sv} <= {uv} should be False"
+    assert out["gt_result"][()] == 1, f"{sv} > {uv} should be True"
+    assert out["ge_result"][()] == 1, f"{sv} >= {uv} should be True"
+    assert out["eq_result"][()] == 0, f"{sv} == {uv} should be False"
+    assert out["ne_result"][()] == 1, f"{sv} != {uv} should be True"
+
+
+@pytest.mark.parametrize("signed_dtype,unsigned_dtype", [
+    (np.int8, np.uint8),
+    (np.int16, np.uint16),
+    (np.int32, np.uint32),
+    (np.int64, np.uint64),
+])
+def test_mixed_sign_subtraction(signed_dtype, unsigned_dtype):
+    """Mixed-sign subtraction must follow Python semantics.
+
+    In C, ``(int32_t)-1 - (uint32_t)1`` is computed as
+    ``(uint32_t)UINT_MAX - 1 = 4294967294``, which when cast to int64
+    gives 4294967294, not -2.  Loopy must insert explicit casts so the
+    result is -2.
+    """
+    # result dtype: the narrowest signed type wide enough to hold both
+    result_dtype = np.result_type(signed_dtype, unsigned_dtype)
+    if result_dtype.kind != "i":
+        # int64 vs uint64: numpy promotes to float64; use int64 instead
+        result_dtype = np.dtype(np.int64)
+
+    t_unit = lp.make_kernel(
+        "{:}",
+        """
+        diff_sv_uv = sv - uv
+        diff_uv_sv = uv - sv
+        """,
+        [
+            lp.ValueArg("sv", signed_dtype),
+            lp.ValueArg("uv", unsigned_dtype),
+            lp.GlobalArg("diff_sv_uv", result_dtype, shape=lp.auto),
+            lp.GlobalArg("diff_uv_sv", result_dtype, shape=lp.auto),
+        ],
+        target=lp.ExecutableCTarget(),
+    )
+    t_unit = lp.set_options(t_unit, return_dict=True)
+
+    # --- sv = -1, uv = 1 → expected -2 / 2 ------------------------------------
+    sv = signed_dtype(-1)
+    uv = unsigned_dtype(1)
+    _evt, out = t_unit(sv=sv, uv=uv)
+    assert out["diff_sv_uv"][()] == -2, \
+        f"{sv} - {uv} should be -2, got {out['diff_sv_uv'][()]}"
+    assert out["diff_uv_sv"][()] == 2, \
+        f"{uv} - {sv} should be 2, got {out['diff_uv_sv'][()]}"
+
+    # --- sv = 5, uv = 3 → expected 2 / -2 -------------------------------------
+    sv = signed_dtype(5)
+    uv = unsigned_dtype(3)
+    _evt, out = t_unit(sv=sv, uv=uv)
+    assert out["diff_sv_uv"][()] == 2, \
+        f"{sv} - {uv} should be 2, got {out['diff_sv_uv'][()]}"
+    assert out["diff_uv_sv"][()] == -2, \
+        f"{uv} - {sv} should be -2, got {out['diff_uv_sv'][()]}"
+
+
 if __name__ == "__main__":
     import sys
     if len(sys.argv) > 1: