MathOverflow warning

[melop]

Hi,

in the std.output, there is this message showing up:

MathOverflow - too small stddev of library (12.7258430875bp) compared to the mean (465.185476795bp) - check distribution. 
10.6473783941 0 0.666666666667
MathOverflow - too small stddev of library (12.7258430875bp) compared to the mean (465.185476795bp) - check distribution. 
13.4981480211 0 0.6
MathOverflow - too small stddev of library (12.7258430875bp) compared to the mean (465.185476795bp) - check distribution. 
87.5604386088 0 0.526315789474

Should I be concerned about this? I determined the stddev of the libraries by mapping with BWA, and the value is similar (the std is very narrow due to a stringent size selection).
Thanks,
Ray

[ksahlin]

Hi,

With this message I would suggest to run with the parameter --no_score for this library. This is more or less because a conditional distribution that BESST use to decide on the score of an edge is tricky to estimate values over. I will leave this issue open until I've fixed a better error message or automated decision to switch to --no_score mode. Thank you for reporting!