diff --git a/Dockerfile b/Dockerfile
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+FROM ubuntu:20.04
+
+ARG DEBIAN_FRONTEND=noninteractive
+
+# Copy content from host to container
+RUN mkdir /shimmer
+COPY . /shimmer
+
+RUN apt-get update && apt-get install -y perl r-base samtools
+
+RUN perl -MCPAN -e 'CPAN::Shell->install("Module::Build")'
+
+# Install R statmod
+RUN R -e "install.packages(c('statmod'),dependencies=TRUE, repos = 'http://cran.rstudio.com/')"
+
+# Install Shimmer
+RUN cd /shimmer && perl /shimmer/Build.PL --install_base /shimmer
+RUN /shimmer/Build
+RUN /shimmer/Build install
+
+ENV PATH="${PATH}:/shimmer/bin"
+ENV PERL5LIB="/shimmer/bin/lib/perl5:${PERL5LIB}"