diff --git a/src/events/defineEvents.js b/src/events/defineEvents.js
index ade7a62..6f83dc8 100644
--- a/src/events/defineEvents.js
+++ b/src/events/defineEvents.js
@@ -56,11 +56,6 @@ export const Mixin = (Super = HTMLElement) => class WithEvents extends Super {
 	// FIXME these won't apply if we're not using NudeElement somewhere in the inheritance chain
 	static mixins = [PropsMixin(Super)];
 
-	constructor () {
-		super();
-		this.init();
-	}
-
 	init () {
 		this.constructor.init();
 
diff --git a/src/form-associated.js b/src/form-associated.js
index 1587f61..8220833 100644
--- a/src/form-associated.js
+++ b/src/form-associated.js
@@ -35,11 +35,6 @@ export function appliesTo (Class) {
 }
 
 export const Mixin = (Super = HTMLElement, { internalsProp = "_internals", configProp = "formAssociated" } = {}) => class FormAssociated extends Super {
-	constructor () {
-		super();
-		this.init();
-	}
-
 	init () {
 		this.constructor[init]();
 
diff --git a/src/hooks/with.js b/src/hooks/with.js
index ba0bd79..f15122b 100644
--- a/src/hooks/with.js
+++ b/src/hooks/with.js
@@ -7,15 +7,7 @@ export function appliesTo (Class) {
 export const Mixin = (Super = HTMLElement) => class WithHooks extends Super {
 	static hooks = new Hooks(super.hooks || {});
 
-	constructor () {
-		super();
-
-		this.init?.();
-	}
-
 	init () {
-		super.init?.();
-
 		const Self = this.constructor;
 
 		if (Self.hooks && !(Self.hooks instanceof Hooks)) {
diff --git a/src/mixins/apply.js b/src/mixins/apply.js
index 0223f3e..55ed32e 100644
--- a/src/mixins/apply.js
+++ b/src/mixins/apply.js
@@ -1,18 +1,42 @@
 import { copyProperties } from "../util/copy-properties.js";
+import { getSuper } from "../util/super.js";
 
 export function applyMixins (Class = this, mixins = Class.mixins) {
 	if (Object.hasOwn(Class, "mixinsActive") || !mixins?.length) {
 		return;
 	}
 
+	// Determine applicable mixins first. Mixins without `appliesTo()` are always applicable.
+	const applicable = mixins.filter(Mixin => Mixin.appliesTo?.(Class) ?? true);
+	if (!applicable.length) {
+		return;
+	}
+
 	Class.mixinsActive = [];
 
-	for (let Mixin of mixins) {
-		if (Mixin.appliesTo && !Mixin.appliesTo(Class)) {
-			// Not applicable to this class
-			continue;
+	// Phase 1: create stubs for all prototype methods from all applicable mixins,
+	// so that they can be used as the base function that mixins can extend.
+	// In that case, none of the mixins' functions is used as the base function to add side effects to.
+	for (const Mixin of applicable) {
+		for (const property of Object.getOwnPropertyNames(Mixin.prototype)) {
+			if (property === "constructor" || Object.hasOwn(Class.prototype, property)) {
+				continue;
+			}
+
+			const descriptor = Object.getOwnPropertyDescriptor(Mixin.prototype, property);
+			if (typeof descriptor.value !== "function") {
+				continue;
+			}
+
+			// Only create a stub if the class doesn't already have its own implementation
+			Class.prototype[property] = function (...args) {
+				getSuper(this, property)?.call(this, ...args);
+			};
 		}
+	}
 
+	// Phase 2: apply all mixins
+	for (let Mixin of applicable) {
 		applyMixin(Class, Mixin);
 	}
 }
@@ -24,10 +48,9 @@ export function applyMixin (Class, Mixin, force = false) {
 		return;
 	}
 
-	copyProperties(Class, Mixin, {recursive: true, prototypes: true});
+	copyProperties(Class, Mixin, { recursive: true, prototypes: true });
 
 	if (!alreadyApplied) {
 		Class.mixinsActive.push(Mixin);
 	}
 }
-
diff --git a/src/props/defineProps.js b/src/props/defineProps.js
index 5fe3f91..5aacf15 100644
--- a/src/props/defineProps.js
+++ b/src/props/defineProps.js
@@ -4,11 +4,6 @@ import { defineLazyProperties } from "../util/lazy.js";
 const { initialized, propsDef } = getSymbols;
 
 export const Mixin = (Super = HTMLElement) => class WithProps extends Super {
-	constructor () {
-		super();
-		this.init();
-	}
-
 	init () {
 		this.constructor.init();
 
diff --git a/src/slots/defineSlots.js b/src/slots/defineSlots.js
index 8b21009..86c3714 100644
--- a/src/slots/defineSlots.js
+++ b/src/slots/defineSlots.js
@@ -3,11 +3,6 @@ import { assignToSlot } from "./util.js";
 let mutationObserver;
 
 export const Mixin = (Super = HTMLElement) => class DefineSlots extends Super {
-	constructor () {
-		super();
-		this.init();
-	}
-
 	init () {
 		if (!this.shadowRoot) {
 			return;
diff --git a/src/styles/global.js b/src/styles/global.js
index f82ccf5..63b9a36 100644
--- a/src/styles/global.js
+++ b/src/styles/global.js
@@ -10,11 +10,6 @@ export function appliesTo (Class) {
 }
 
 export const Mixin = (Super = HTMLElement) => class GlobalStyles extends Super {
-	constructor () {
-		super();
-		this.init();
-	}
-
 	async [render] () {
 		let Self = this.constructor;
 
diff --git a/src/styles/shadow.js b/src/styles/shadow.js
index 3606616..6e35e1b 100644
--- a/src/styles/shadow.js
+++ b/src/styles/shadow.js
@@ -10,11 +10,6 @@ export function appliesTo (Class) {
 }
 
 export const Mixin = (Super = HTMLElement) => class ShadowStyles extends Super {
-	constructor () {
-		super();
-		this.init();
-	}
-
 	init () {
 		if (!this.shadowRoot) {
 			return;