diff --git a/.github/workflows/full-stack.yaml b/.github/workflows/full-stack.yaml
index 9cefc8f..e6c5342 100644
--- a/.github/workflows/full-stack.yaml
+++ b/.github/workflows/full-stack.yaml
@@ -45,14 +45,12 @@ jobs:
       with:
         repository: openforcefield/openff-qcsubmit
         path: openff-qcsubmit
-        fetch-depth: 0
 
     - name: Checkout OpenFF Fragmenter
       uses: actions/checkout@v7
       with:
         repository: openforcefield/openff-fragmenter
         path: openff-fragmenter
-        fetch-depth: 0
 
     - name: Checkout OpenFF Units
       uses: actions/checkout@v7
@@ -65,7 +63,6 @@ jobs:
       with:
         repository: openforcefield/openff-utilities
         path: openff-utilities
-        fetch-depth: 0
 
     - name: Set up conda environment
       uses: mamba-org/setup-micromamba@v3
@@ -80,7 +77,7 @@ jobs:
 
     - name: Install most recent development versions
       run: |
-        python -m pip install -e \
+        python -m uv pip install -e --no-deps \
           openff-interchange/ \
           openff-interchange/plugins/ \
           openff-qcsubmit/ \
diff --git a/devtools/conda-envs/full-stack.yaml b/devtools/conda-envs/full-stack.yaml
index a4d8b87..7ce038c 100644
--- a/devtools/conda-envs/full-stack.yaml
+++ b/devtools/conda-envs/full-stack.yaml
@@ -1,18 +1,18 @@
 name: full-stack-tests
 channels:
-  - openeye
   - conda-forge
 dependencies:
   - python
-  - setuptools =81
+  - uv
+  - setuptools
   - pip
-  - numpy >=2.4
-  - pydantic =2.11.10
-  - pint >=0.25
-  - openff-toolkit >=0.18
-  - ambertools =24.8  # just to help solver
+  - numpy
+  - pydantic
+  - pint
+  - openff-toolkit-base
   - openff-fragmenter
-  - openff-interchange >=0.5.2
+  - openff-packmol
+  - openmm
   - mdtraj
   - pymbar
   - pytest
@@ -24,29 +24,25 @@ dependencies:
   - toml
   - bson
   - msgpack-python
-  - openeye-toolkits >=2025
-  - rdkit >=2025.09.5
+  - openeye::openeye-toolkits
+  - rdkit
   - intermol
 
     # Recharge
   - qcelemental
-  - qcportal >=0.59
   - qcengine
   - geometric
 
   - openff-qcsubmit
+  - qcportal
   - qcarchivetesting
   - qcfractalcompute
-  - h5py =3.16
-  - psi4 =1.9.1
+  - h5py
+  - psi4
 
   - openff-nagl >=0.5
   - pytorch =2.8
   - pytorch-lightning =2.6.1
 
-  - gromacs >=2024
-  # https://github.com/conda-forge/lammps-feedstock/issues/207
-  - lammps >=2024.08.29
-  - openmpi =4
-
-  - icu=75 # just to help solver
+  - gromacs
+  # lammps