diff --git a/packages/react-native/Package.swift b/packages/react-native/Package.swift
index d95d1c6a1d3c..8653c0505251 100644
--- a/packages/react-native/Package.swift
+++ b/packages/react-native/Package.swift
@@ -593,7 +593,11 @@ let reactRCTBlob = RNTarget(
 let reactRCTNetwork = RNTarget(
   name: .reactRCTNetwork,
   path: "Libraries/Network",
-  dependencies: [.yoga, .jsi, .reactTurboModuleCore]
+  dependencies: [.yoga, .jsi, .reactTurboModuleCore],
+  defines: [
+    CXXSetting.define("REACT_NATIVE_DEBUGGER_ENABLED", to: "1", .when(configuration: BuildConfiguration.debug)),
+    CXXSetting.define("REACT_NATIVE_DEBUGGER_ENABLED_DEVONLY", to: "1", .when(configuration: BuildConfiguration.debug)),
+  ]
 )
 
 /// React-RCTVibration.podspec
diff --git a/packages/react-native/ReactAndroid/src/main/jni/CMakeLists.txt b/packages/react-native/ReactAndroid/src/main/jni/CMakeLists.txt
index 0e7e429d2c0e..dc7447d202c8 100644
--- a/packages/react-native/ReactAndroid/src/main/jni/CMakeLists.txt
+++ b/packages/react-native/ReactAndroid/src/main/jni/CMakeLists.txt
@@ -338,3 +338,10 @@ target_include_directories(reactnative
         $<TARGET_PROPERTY:uimanagerjni,INTERFACE_INCLUDE_DIRECTORIES>
         $<TARGET_PROPERTY:yoga,INTERFACE_INCLUDE_DIRECTORIES>
 )
+
+if(${CMAKE_BUILD_TYPE} MATCHES Debug OR REACT_NATIVE_DEBUG_OPTIMIZED)
+  target_compile_options(reactnative PRIVATE
+          -DREACT_NATIVE_DEBUGGER_ENABLED=1
+          -DREACT_NATIVE_DEBUGGER_ENABLED_DEVONLY=1
+  )
+endif ()
diff --git a/packages/react-native/ReactAndroid/src/main/jni/react/devsupport/CMakeLists.txt b/packages/react-native/ReactAndroid/src/main/jni/react/devsupport/CMakeLists.txt
index 3905a4af4ad1..b1a528edf8d2 100644
--- a/packages/react-native/ReactAndroid/src/main/jni/react/devsupport/CMakeLists.txt
+++ b/packages/react-native/ReactAndroid/src/main/jni/react/devsupport/CMakeLists.txt
@@ -23,3 +23,10 @@ target_link_libraries(react_devsupportjni
         react_networking)
 
 target_compile_reactnative_options(react_devsupportjni PRIVATE)
+
+if(${CMAKE_BUILD_TYPE} MATCHES Debug OR REACT_NATIVE_DEBUG_OPTIMIZED)
+  target_compile_options(react_devsupportjni PRIVATE
+          -DREACT_NATIVE_DEBUGGER_ENABLED=1
+          -DREACT_NATIVE_DEBUGGER_ENABLED_DEVONLY=1
+  )
+endif ()
diff --git a/packages/react-native/scripts/cocoapods/utils.rb b/packages/react-native/scripts/cocoapods/utils.rb
index d87c0e22d51d..a24489637f28 100644
--- a/packages/react-native/scripts/cocoapods/utils.rb
+++ b/packages/react-native/scripts/cocoapods/utils.rb
@@ -58,9 +58,11 @@ def self.set_gcc_preprocessor_definition_for_React_hermes(installer)
 
     def self.set_gcc_preprocessor_definition_for_debugger(installer)
         self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED=1", "React-jsinspector", :debug)
+        self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED=1", "React-jsinspectornetwork", :debug)
         self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED=1", "React-RCTNetwork", :debug)
         self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED=1", "React-networking", :debug)
         self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED_DEVONLY=1", "React-jsinspector", :debug)
+        self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED_DEVONLY=1", "React-jsinspectornetwork", :debug)
         self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED_DEVONLY=1", "React-RCTNetwork", :debug)
         self.add_build_settings_to_pod(installer, "GCC_PREPROCESSOR_DEFINITIONS", "REACT_NATIVE_DEBUGGER_ENABLED_DEVONLY=1", "React-networking", :debug)
     end