diff --git a/README.md b/README.md
index 3a1d8172..7177f631 100644
--- a/README.md
+++ b/README.md
@@ -72,3 +72,38 @@ import { interceptors } from "./grpc-devtools";
 
 const transport = createConnectTransport({ baseUrl: "http://localhost:3003", interceptors });
 ```
+
+## [protobuf-ts](https://github.com/timostamm/protobuf-ts)
+
+grpc-devtools.ts
+
+```ts
+import type { RpcInterceptor } from "@protobuf-ts/runtime-rpc";
+
+declare const __gRPC_devtools__:
+  | undefined
+  | {
+      protobufTsInterceptor: RpcInterceptor;
+    };
+
+export const interceptors: RpcInterceptor[] =
+  typeof __gRPC_devtools__ === "object"
+    ? [
+        __gRPC_devtools__.protobufTsInterceptor,
+      ]
+    : [];
+```
+
+example.ts
+
+```ts
+import { GrpcWebFetchTransport } from "@protobuf-ts/grpcweb-transport";
+import { interceptors } from "./grpc-devtools";
+
+const transport = new GrpcWebFetchTransport({
+  baseUrl: "http://localhost:8080",
+  interceptors,
+});
+```
+
+For a standalone snippet-only example, see [`example/protobuf-ts`](./example/protobuf-ts).
diff --git a/__tests__/grpc-web.ts b/__tests__/grpc-web.ts
index 66c975dc..29cecd6b 100644
--- a/__tests__/grpc-web.ts
+++ b/__tests__/grpc-web.ts
@@ -1,9 +1,18 @@
 const fs = require("fs");
 const path = require("path");
 
-test("__GRPCWEB_DEVTOOLS__", () => {
+test("__GRPCWEB_DEVTOOLS__ grpc-web internals include interceptor arrays", () => {
   const grpcWebIndexPath = path.resolve(__dirname, "..", "node_modules", "grpc-web", "index.js");
   const grpcWebIndexContent = fs.readFileSync(grpcWebIndexPath, "utf-8");
 
-  expect(grpcWebIndexContent).toContain("this.b=[];this.h=[];this.g=[];this.f=[];this.c=[]");
+  // grpc-web internals are minified and changed between versions.
+  // Accept both older (h/g/b) and newer (h/m) interceptor field layouts.
+  const hasLegacyLayout =
+    grpcWebIndexContent.includes("this.h=[]") &&
+    grpcWebIndexContent.includes("this.g=[]") &&
+    grpcWebIndexContent.includes("this.b=[]");
+  const hasModernLayout =
+    grpcWebIndexContent.includes("this.h=[]") && grpcWebIndexContent.includes("this.m=[]");
+
+  expect(hasLegacyLayout || hasModernLayout).toBe(true);
 });
diff --git a/__tests__/protobuf-ts.ts b/__tests__/protobuf-ts.ts
new file mode 100644
index 00000000..dad2cd49
--- /dev/null
+++ b/__tests__/protobuf-ts.ts
@@ -0,0 +1,48 @@
+const fs = require("fs");
+const path = require("path");
+
+test("protobuf-ts interceptor is exposed in injected globals", () => {
+  const indexPath = path.resolve(__dirname, "..", "content-scripts", "src", "main", "index.ts");
+  const content = fs.readFileSync(indexPath, "utf-8");
+
+  expect(content).toContain("protobufTsInterceptor");
+  expect(content).toContain("value: protobufTsInterceptor");
+});
+
+test("protobuf-ts interceptor handles unary and server streaming flows", () => {
+  const filePath = path.resolve(
+    __dirname,
+    "..",
+    "content-scripts",
+    "src",
+    "main",
+    "protobuf-ts.ts",
+  );
+  const content = fs.readFileSync(filePath, "utf-8");
+
+  expect(content).toContain("interceptUnary");
+  expect(content).toContain("interceptServerStreaming");
+  expect(content).toContain('responseMessage: "EOF"');
+  expect(content).toContain("toMetadataRecord(call.requestHeaders)");
+  expect(content).toContain("mergeMetadata");
+  expect(content).toContain("void call.headers");
+  expect(content).toContain("void call.trailers");
+  expect(content).toContain("responseMetadata = mergeMetadata(headers, responseMetadata)");
+  expect(content).toContain("responseMetadata = mergeMetadata(responseMetadata, trailers)");
+});
+
+test("protobuf-ts interceptor avoids creating unhandled rejections", () => {
+  const filePath = path.resolve(
+    __dirname,
+    "..",
+    "content-scripts",
+    "src",
+    "main",
+    "protobuf-ts.ts",
+  );
+  const content = fs.readFileSync(filePath, "utf-8");
+
+  expect(content).toContain("void call");
+  expect(content).toContain(".catch((error: RpcError) => {");
+  expect(content).not.toContain("throw error");
+});
diff --git a/content-scripts/package.json b/content-scripts/package.json
index 61d91891..407cb85c 100644
--- a/content-scripts/package.json
+++ b/content-scripts/package.json
@@ -9,6 +9,7 @@
   },
   "devDependencies": {
     "@connectrpc/connect": "2.1.0",
+    "@protobuf-ts/runtime-rpc": "^2.11.1",
     "@types/chrome": "0.1.37",
     "@types/google-protobuf": "3.15.12",
     "grpc-web": "2.0.2",
diff --git a/content-scripts/src/main/index.ts b/content-scripts/src/main/index.ts
index 6f13c7af..450ddba3 100644
--- a/content-scripts/src/main/index.ts
+++ b/content-scripts/src/main/index.ts
@@ -7,6 +7,7 @@ import {
   gRPCWebUnaryInterceptor,
   gRPCWebUnaryInterceptorInstance,
 } from "./grpc";
+import { protobufTsInterceptor } from "./protobuf-ts";
 
 declare global {
   interface Window {
@@ -14,6 +15,7 @@ declare global {
       gRPCWebUnaryInterceptor: gRPCWebUnaryInterceptor<Message, Message>;
       gRPCWebStreamInterceptor: gRPCWebStreamInterceptor<Message, Message>;
       connectEsInterceptor: Interceptor;
+      protobufTsInterceptor: typeof protobufTsInterceptor;
     };
   }
 }
@@ -47,4 +49,8 @@ Object.defineProperties(window.__gRPC_devtools__, {
     value: connectEsInterceptor,
     writable: false,
   },
+  protobufTsInterceptor: {
+    value: protobufTsInterceptor,
+    writable: false,
+  },
 });
diff --git a/content-scripts/src/main/protobuf-ts.ts b/content-scripts/src/main/protobuf-ts.ts
new file mode 100644
index 00000000..6d6907f7
--- /dev/null
+++ b/content-scripts/src/main/protobuf-ts.ts
@@ -0,0 +1,156 @@
+import type {
+  NextServerStreamingFn,
+  NextUnaryFn,
+  RpcError,
+  RpcInterceptor,
+  RpcMetadata,
+  ServerStreamingCall,
+  UnaryCall,
+} from "@protobuf-ts/runtime-rpc";
+import { postMessageToContentScript } from "./post-message-to-content-script";
+
+const toMetadataRecord = (
+  metadata: undefined | Readonly<RpcMetadata>,
+): Record<string, string> | undefined => {
+  if (metadata === undefined) {
+    return undefined;
+  }
+
+  return Object.entries(metadata).reduce<Record<string, string>>(
+    (
+      acc,
+      [
+        key,
+        value,
+      ],
+    ) => {
+      acc[key] = Array.isArray(value) ? value.map(String).join(", ") : String(value);
+      return acc;
+    },
+    {},
+  );
+};
+
+const mergeMetadata = (
+  ...metadataItems: Array<undefined | Readonly<RpcMetadata>>
+): Record<string, string> | undefined => {
+  const records = metadataItems
+    .map((metadata) => toMetadataRecord(metadata))
+    .filter((metadata): metadata is Record<string, string> => metadata !== undefined);
+
+  if (records.length === 0) {
+    return undefined;
+  }
+
+  return Object.assign({}, ...records);
+};
+
+const toSerializableError = (error: RpcError) => ({
+  name: error.name,
+  code: error.code,
+  message: error.message,
+  stack: error.stack,
+});
+
+export const protobufTsInterceptor: RpcInterceptor = {
+  interceptUnary(next: NextUnaryFn, method, input, options): UnaryCall {
+    const id = Math.random().toString(36).slice(2, 6);
+    const call = next(method, input, options);
+
+    postMessageToContentScript({
+      id,
+      methodName: method.name,
+      serviceName: method.service.typeName,
+      requestMessage: call.request,
+      requestMetadata: toMetadataRecord(call.requestHeaders),
+    });
+
+    void call
+      .then((finishedUnaryCall) => {
+        postMessageToContentScript({
+          id,
+          responseMetadata: mergeMetadata(finishedUnaryCall.headers, finishedUnaryCall.trailers),
+          responseMessage: finishedUnaryCall.response,
+        });
+
+        postMessageToContentScript({
+          id,
+          responseMessage: "EOF",
+        });
+      })
+      .catch((error: RpcError) => {
+        postMessageToContentScript({
+          id,
+          responseMessage: toSerializableError(error),
+          errorMetadata: toMetadataRecord(error.meta),
+        });
+      });
+
+    return call;
+  },
+
+  interceptServerStreaming(
+    next: NextServerStreamingFn,
+    method,
+    input,
+    options,
+  ): ServerStreamingCall {
+    const id = Math.random().toString(36).slice(2, 6);
+    const call = next(method, input, options);
+    let responseMetadata: Record<string, string> | undefined;
+
+    void call.headers
+      .then((headers) => {
+        responseMetadata = mergeMetadata(headers, responseMetadata);
+        postMessageToContentScript({
+          id,
+          responseMetadata,
+        });
+      })
+      .catch(() => void 0);
+
+    void call.trailers
+      .then((trailers) => {
+        responseMetadata = mergeMetadata(responseMetadata, trailers);
+        postMessageToContentScript({
+          id,
+          responseMetadata,
+        });
+      })
+      .catch(() => void 0);
+
+    postMessageToContentScript({
+      id,
+      methodName: method.name,
+      serviceName: method.service.typeName,
+      requestMetadata: toMetadataRecord(call.requestHeaders),
+      requestMessage: call.request,
+    });
+
+    call.responses.onMessage((message) => {
+      postMessageToContentScript({
+        id,
+        responseMetadata,
+        responseMessage: message,
+      });
+    });
+
+    call.responses.onComplete(() => {
+      postMessageToContentScript({
+        id,
+        responseMetadata,
+        responseMessage: "EOF",
+      });
+    });
+
+    call.responses.onError((error) => {
+      postMessageToContentScript({
+        id,
+        responseMessage: toSerializableError(error),
+        errorMetadata: toMetadataRecord(error.meta),
+      });
+    });
+
+    return call;
+  },
+};
diff --git a/docs/issue-101-protobuf-ts-plan.md b/docs/issue-101-protobuf-ts-plan.md
new file mode 100644
index 00000000..b6c5bce5
--- /dev/null
+++ b/docs/issue-101-protobuf-ts-plan.md
@@ -0,0 +1,42 @@
+# Issue #101 Plan: Integrate protobuf-ts support
+
+## Goal
+
+Add first-class support for applications using `protobuf-ts` with gRPC-Web transport so requests and responses are captured in gRPC Devtools without custom user code.
+
+## Delivery plan
+
+1. **Expose a built-in protobuf-ts interceptor in injected globals**
+   - Add `window.__gRPC_devtools__.protobufTsInterceptor` to the main injected entrypoint.
+   - Keep existing `gRPC-Web` and `Connect-ES` support unchanged.
+
+2. **Implement protobuf-ts interceptor behavior**
+   - Add unary interception:
+     - send request metadata and request message;
+     - send response metadata + response message;
+     - send EOF marker;
+     - capture and forward error metadata/message details.
+   - Add server-streaming interception:
+     - send initial request metadata and message;
+     - forward each streamed message;
+     - send EOF on completion;
+     - send structured error payload on stream errors.
+
+3. **Normalize protobuf-ts metadata for Devtools transport format**
+   - Convert `Record<string, string | string[]>` metadata to `Record<string, string>` for existing message pipeline compatibility.
+
+4. **Document public usage in README**
+   - Add a `protobuf-ts` section with a `grpc-devtools.ts` snippet and transport wiring example for `@protobuf-ts/grpcweb-transport`.
+
+5. **Add a dedicated protobuf-ts example**
+   - Add a self-contained example directory under `example/protobuf-ts` that demonstrates interceptor wiring with `GrpcWebFetchTransport`.
+
+6. **Validation**
+   - Build content scripts to ensure TypeScript/webpack compilation succeeds.
+   - Build the full extension workspace to verify no regressions across packages.
+
+## Non-goals (for this PR)
+
+- Auto-detection/injection into user transports without adding the interceptor.
+- New UI behavior in Devtools panel.
+- Support beyond unary and server-streaming APIs used in gRPC-Web transport.
diff --git a/example/protobuf-ts/README.md b/example/protobuf-ts/README.md
new file mode 100644
index 00000000..ac49abf0
--- /dev/null
+++ b/example/protobuf-ts/README.md
@@ -0,0 +1,39 @@
+# protobuf-ts Example
+
+This example shows how to wire `grpc-devtools` with [`protobuf-ts`](https://github.com/timostamm/protobuf-ts) and the gRPC-Web transport.
+
+## grpc-devtools.ts
+
+```ts
+import type { RpcInterceptor } from "@protobuf-ts/runtime-rpc";
+
+declare const __gRPC_devtools__:
+  | undefined
+  | {
+      protobufTsInterceptor: RpcInterceptor;
+    };
+
+export const interceptors: RpcInterceptor[] =
+  typeof __gRPC_devtools__ === "object"
+    ? [
+        __gRPC_devtools__.protobufTsInterceptor,
+      ]
+    : [];
+```
+
+## transport.ts
+
+```ts
+import { GrpcWebFetchTransport } from "@protobuf-ts/grpcweb-transport";
+import { interceptors } from "./grpc-devtools";
+
+export const transport = new GrpcWebFetchTransport({
+  baseUrl: "http://localhost:3003",
+  interceptors,
+});
+```
+
+## Included source snippets
+
+- `client/src/grpc-devtools.ts`
+- `client/src/transport.ts`
diff --git a/example/protobuf-ts/client/src/grpc-devtools.ts b/example/protobuf-ts/client/src/grpc-devtools.ts
new file mode 100644
index 00000000..41f8301d
--- /dev/null
+++ b/example/protobuf-ts/client/src/grpc-devtools.ts
@@ -0,0 +1,14 @@
+import type { RpcInterceptor } from "@protobuf-ts/runtime-rpc";
+
+declare const __gRPC_devtools__:
+  | undefined
+  | {
+      protobufTsInterceptor: RpcInterceptor;
+    };
+
+export const interceptors: RpcInterceptor[] =
+  typeof __gRPC_devtools__ === "object"
+    ? [
+        __gRPC_devtools__.protobufTsInterceptor,
+      ]
+    : [];
diff --git a/example/protobuf-ts/client/src/transport.ts b/example/protobuf-ts/client/src/transport.ts
new file mode 100644
index 00000000..0aa0df8e
--- /dev/null
+++ b/example/protobuf-ts/client/src/transport.ts
@@ -0,0 +1,7 @@
+import { GrpcWebFetchTransport } from "@protobuf-ts/grpcweb-transport";
+import { interceptors } from "./grpc-devtools";
+
+export const transport = new GrpcWebFetchTransport({
+  baseUrl: "http://localhost:3003",
+  interceptors,
+});
diff --git a/package-lock.json b/package-lock.json
index 3a39999f..d00501d5 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -30,6 +30,7 @@
       "license": "GPL-3.0",
       "devDependencies": {
         "@connectrpc/connect": "2.1.0",
+        "@protobuf-ts/runtime-rpc": "^2.11.1",
         "@types/chrome": "0.1.37",
         "@types/google-protobuf": "3.15.12",
         "grpc-web": "2.0.2",
@@ -2393,6 +2394,23 @@
         "url": "https://opencollective.com/popperjs"
       }
     },
+    "node_modules/@protobuf-ts/runtime": {
+      "version": "2.11.1",
+      "resolved": "https://registry.npmjs.org/@protobuf-ts/runtime/-/runtime-2.11.1.tgz",
+      "integrity": "sha512-KuDaT1IfHkugM2pyz+FwiY80ejWrkH1pAtOBOZFuR6SXEFTsnb/jiQWQ1rCIrcKx2BtyxnxW6BWwsVSA/Ie+WQ==",
+      "dev": true,
+      "license": "(Apache-2.0 AND BSD-3-Clause)"
+    },
+    "node_modules/@protobuf-ts/runtime-rpc": {
+      "version": "2.11.1",
+      "resolved": "https://registry.npmjs.org/@protobuf-ts/runtime-rpc/-/runtime-rpc-2.11.1.tgz",
+      "integrity": "sha512-4CqqUmNA+/uMz00+d3CYKgElXO9VrEbucjnBFEjqI4GuDrEQ32MaI3q+9qPBvIGOlL4PmHXrzM32vBPWRhQKWQ==",
+      "dev": true,
+      "license": "Apache-2.0",
+      "dependencies": {
+        "@protobuf-ts/runtime": "^2.11.1"
+      }
+    },
     "node_modules/@react-aria/focus": {
       "version": "3.20.2",
       "resolved": "https://registry.npmjs.org/@react-aria/focus/-/focus-3.20.2.tgz",