• Developed ML models to predict tumor response post-Cyberknife®️ radiosurgery using radiomic features from pre-treatment MRI. • Extracted 851 features using PyRadiomics; performed preprocessing (bias correction, normalization) and 3D segmentation with 3D Slicer. • Trained and evaluated classifiers (Neural Network, SVM, XGBoost, Random Forest) using nested cross-validation and LASSO-based feature selection. • Achieved 73% balanced accuracy at 24 months with Neural Network; handled class imbalance using SMOTE. • Built a FastAPI-based web service to deploy the prediction pipeline, enabling MRI file upload and automated response prediction.