How are DPP4 interactions classified?

[dnjst]

Dear developers,

Congratulations on cellphonedb v5! I love the fact that this version includes the "classification" and "directionality" metadata.

I was wondering, in the interactions where DPP4 is listed as a receptor - does this protein act as a receptor for all of these ligands? Or is it modifying circulating chemokines by cleaving them to activate or inhibit them? Because currently it is classified as "Ligand-Receptor".I don't know the cell biology well enough to interpret these results - Thanks.

[datasome]

Dear dnjst,

Thank you for your inquiry and my apologies for the delayed reply. We're currently somewhat short on curation capacity but to try and answer your question, https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08051.x would suggest that DPP4 does indeed CCL11 to activate/inhibit it. It may just be that CellphoneDB curators have chosen not to use a special 'directionality' value for this and just stuck to Ligand-Receptor. If I manage to find out more, I will let you know.

Best,

Robert.