TBI Outcomes Consortium — open infrastructure for harmonizing outcome measurement across TBI research and clinical practice. Aligned with TRACK-TBI, InTBIR, and COMET core outcome set work.
Active reference repository. Harmonization schemas in development.
outcomes/— Structured definitions for all TBI outcome instruments (GOSE, GOS, RPQ, PCSI, PROMIS-TBI)crosswalks/— Instrument-to-instrument crosswalk tables (GOSE ↔ GOS ↔ mRS)validation/— Psychometric validation summaries (COSMIN-standard summaries per instrument)cosmin/— COSMIN systematic review findings for TBI-relevant outcome measuresregistry/— CDE registry aligned to TRACK-TBI General Core + Emerging Core
TBI clinical trials use incompatible outcome instruments, follow-up windows, and reporting conventions. The result is that meta-analysis requires arbitrary assumptions, and cross-trial comparison is unreliable. The TBI Outcomes Consortium addresses this by:
- Mapping all major TBI outcome instruments to a common CDE schema
- Providing validated crosswalk coefficients where psychometric evidence supports them
- Flagging where crosswalks are unsupported (the honest answer is often "these instruments are not equivalent")
- Supporting the TRACK-TBI General Core + Emerging Core implementation framework
The outcome instrument definitions here are grounded in COSMIN (Consensus-based Standards for the Selection of Health Measurement Instruments) reviews. This includes:
- ICC values for GOSE and extended GOSE (remote vs. in-person administration)
- RPQ test-retest reliability in telehealth contexts
- PCSI factor structure in pediatric TBI
Contributions from neuropsychologists, outcome researchers, and clinical trialists are welcome. All instrument crosswalks must include a psychometric evidence basis. See CONTRIBUTING.md.
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EvidenceOS Research Lab — outcomes@evidenceos.com
cbim-framework— CBI-M patient classification (input side)tbi-prediction-models— Outcome-stratified prediction modelsevidence-commons— Living systematic review using these outcomes