BRCA: Breast Cancer Multi-Omics Analysis

Overview

Multi-omics analysis of Breast Cancer (BRCA) with focus on Mendelian Randomization (MR) and data integration. The project uses GWAS summary statistics for causal inference between exposures and breast cancer outcomes.

Analysis Pipeline

Script	Description
MR 结局本地下载后进行MRinstrument分析 20250508 - 1~6.R	Two-sample Mendelian Randomization analysis across 6 exposure-outcome pairs
数据整合.R	Data integration and harmonization
STROBE-checklist-20250511.docx	STROBE reporting checklist for observational studies

Key Methods

• Two-Sample MR — Causal inference using GWAS summary data
• MR Instrument Selection — Systematic instrument variable selection across 6 analyses
• Data Integration — Harmonization of multiple exposure-outcome datasets
• STROBE Compliance — Adherence to Strengthening the Reporting of Observational Studies

Requirements

• R ≥ 4.0
• Key packages: TwoSampleMR, MRInstruments, ieugwasr

License

Research use only.