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Welcome to the Age-dependent-Reference-Intervals_Generator (AdRI_Generator) Wiki!
This Shiny App is a generator for creating age-dependent analyt-data. The generated data can be downloaded and used in the Shiny App AdRI (See the Wiki).
Available are the following distributions: Normal-Distribution (NO), Log-Normal-Distribution (LOGNO), Box-Cox Cole & Green Distribution (BCCG), Box-Cox t-Distribution (BCT) and Box-Cox Power Exponential Distribution (BCPE). The parameters μ (Mean), σ (Variance), ν (Skewness) and τ (Kurtosis) are changing over the patient age with a linear or an exponential function.
The linear function is: y = m*x + b and the exponential y = a*e^(x*b).
The data can be downloaded as a CSV file. Negative values are deleted automatically. The generator save "Generator" as the stations-name and determines that all values are unique and have no gender. To add pathological cases (only by Normal-Distribution) a factor can be added to μ.
Normally distributed data can be generated with given reference intervals (Data for the reference intervals must be from normally distributed analytes!). Use the Percentile_Table_Template.csv as template for this. The formula to calculate µ and σ is: µ = (LL + UL)/2 and σ = (UL - LL)/3.92 (Lower and upper reference limits LL and UL).
- R ≥ 4.1.2
- DT ≥ 0.21
- shiny ≥ 1.7.1
- shinydashboard ≥ 0.7.2
- gamlss ≥ 5.4-1
You are welcome to:
- Submit suggestions and bugs at: https://github.com/SandraKla/AdRI_Generator/issues
- Make a pull request on: https://github.com/SandraKla/AdRI_Generator/pulls
Only anonymized data may be uploaded to this application. This application is provided “as is” and “as available”, without any express or implied warranties of any kind. No warranty is given regarding the accuracy, completeness, reliability, or timeliness of the results. The results are provided for informational and research purposes only and must not be used for diagnosis, treatment, prevention, or any form of clinical or medical decision-making. This application is not a medical device or medical product and does not replace professional medical advice. To the fullest extent permitted by law, the author disclaims all liability for any direct, indirect, incidental, consequential, or special damages arising from the use of this application or its results. Use of this application is entirely at your own risk.
Zierk J, Hirschmann J, Toddenroth D, et al. Next-generation reference intervals for pediatric hematology. Clin Chem Lab Med. 2019;57(10):1595‐1607. 10.1515/cclm-2018-1236
Zierk J, Arzideh F, Rechenauer T, et al. Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence. Clin Chem. 2015;61(7):964‐973. 10.1373/clinchem.2015.239731
Hoffmann, G., Klawonn, F., Lichtinghagen, R., & Orth, M. (2017). Der zlog-Wert als Basis für die Standardisierung von Laborwerten, Journal of Laboratory Medicine, 41(1), 23-32. https://doi.org/10.1515/labmed-2016-0087