TF-NRD: Transcription Factors Non-Redundant Dataset

TF-NRD is a curated non-redundant dataset of transcription factor (TF) sequences and structures, designed to support structural and functional analysis of TF assemblies across domains of life.

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🔬 Overview

Transcription factors (TFs) are key regulators of gene expression. They interact with various biomolecules, including DNA, RNA, DNA–RNA hybrids, and proteins, to perform their regulatory functions.

The TF-NRD dataset provides a comprehensive and non-redundant collection of TFs to facilitate:

• Structural analysis of TF complexes
• Understanding TF binding mechanisms
• Development of predictive computational models
• Exploration of TF interaction diversity

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✨ Highlights

• TFs play critical roles in gene regulation
• TFs interact with:
  • DNA
  • RNA
  • DNA–RNA hybrids
  • Protein partners
• Structural diversity of TFs enables unique interaction interfaces
• Provides an atlas for studying TF assemblies across biological domains
• Useful for computational prediction and modeling of TF interactions

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📁 Directory Structure

TF_NRD/
│
├── Code/ # Scripts and processing pipelines
├── PDB/ # Structural data
│ ├── TF_DNA/
│ ├── TF_DNA_RNA/
│ └── TF_RNA/
│
├── Sequences/ # TF sequence datasets
├── Supplementary/ # Additional supporting data

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🌐 Availability

The dataset is publicly available at:

🔗 http://www.csb.iitkgp.ac.in/databases/TFNRDv1.0/tfnrd.html

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📖 Reference

Garai, S., Kant, S., & Bahadur, R. P. (2026).
An atlas of non-redundant sequences and structures of transcription factor assemblies across domains of life.

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📌 Citation

If you use this dataset in your research, please cite the above reference.

📜 License

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