KinaseCanvas

KinaseCanvas integrates the Kinase Specificity Atlas (Ser/Thr + Tyr, formerly the Cantley Atlas) and curated kinase–substrate interactions. It includes the supporting data inputs, derived network summaries, Quarto viewers, and analysis R Markdown used to generate the figures and JSON payloads.

Contents

• data/ – Specificity Atlas CSVs, kinetic reference tables, and supporting XLSX files.
• figures/paper_figures/ – Exported manuscript-ready figures (PNG/PDF).
• results/ – CSV exports powering the interactive network viewers.
• src/ – Quarto and R Markdown sources for the data integration and viewers.

Live interactive viewer

• GitHub Pages: https://cujoisa.github.io/KinaseCanvas/

How to use the viewer

• Pick a kinase (and optionally a substrate) in the top controls to seed the network.
• Toggle layouts, functional-only edges, node/edge labels, and arrows to declutter dense regions.
• Filter the table by typing in column filters; the table always reflects what is visible in the graph.
• Export: PNG/PDF for figures, and CSV for the currently visible edges (includes Sites and Reference_PMID).

Reproducing the analysis

1. Install packages recorded in renv.lock using renv::restore().
2. Knit src/generate_kinase_substrate_graph_tyrosine_updated.Rmd to rebuild the integrated dataset and figures.
3. Render the Quarto documents under src/ to regenerate the HTML network viewers.