WiNGS is built as a federated ecosystem in which all sensitive data remains on the premises of registered users (e.g., a genetic center) and is queried through a centralized interface. This architecture enables secure cross-center collaboration while supporting anonymized statistical analysis.
WiNGS also functions as an analysis platform for Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) data, enabling users to process, analyze, and interpret large-scale genomic datasets via the REST API within the same secure environment.
The platform’s core functionality—including genomic data analysis—is exposed to end users through the REST API, while administrative features such as user management and filter creation are managed through a web-based interface.
To setup WiNGS, we provide a manual here (mongoDB) and here (annotations). In order to finalize the setup, you will have to register in the central infrastructure as well. To do so, please contact us.
Several repositories are available under this account. They are organized as follows:
flowchart TD;
A[wings-public] --> B[CENTRAL INFRASTRUCTURE];
A --> C[FEDERATED INFRASTRCUTURE];
B --> D["wings_cdb<br/>-------<br/>Central MSSQL database"]
B --> E["wings_ui<br/>-------<br/>ASP.NET code of the Web-Interface"]
B --> L["wings_rest_api<br/>-------<br/>API code for user interaction with WiNGS"]
C --> F["wings_api_internal<br/>-------<br/>-Routines to communicate with central infrastructure<br/>-Routines to communicate with Annotation infrastructure<br/>-MongDB database"]
C --> G["wings_anno_api<br/>-------<br/>-Routines to manage annotation tasks<br/>-Optional, can be used centrally"]
G --> H["annotation_parser<br/>-------<br/>Routines to combine annotations from different subtasks"]
G --> I["vep_annotations<br/>-------<br/>Extended container to perform Ensmbel VEP"]
G --> J["cadd_annotations<br/>-------<br/>Extended container to perform cadd scoring"]
C --> K["wings_rstats<br/>-------<br/>R deployment to perform anonymized statistics"]
An overview of the capabilities of WiNGS is available on youtube
WiNGS is available under the GNU Affero General Public License Version 3
If you have questions, feel free to reach out at geert.vandeweyer@uza.be