Investigate transdermal patch PK calculation: total dose vs. release rate relationship#23
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Investigate transdermal patch PK calculation: total dose vs. release rate relationship#23NaiveTomcat with Copilot wants to merge 1 commit into
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[WIP] Explain logic for calculating transdermal patch dosage and release rate
Investigate transdermal patch PK calculation: total dose vs. release rate relationship
Mar 10, 2026
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The issue asked to clarify the relationship between total dose (
doseMG) and release rate (RELEASE_RATE_UG_PER_DAY) in the transdermal patch pharmacokinetic model.Findings
The codebase already implements two distinct, intentional modes in
ParameterResolver.resolvePatchApply():RELEASE_RATE_UG_PER_DAYpresent inextras): Zero-order kinetics. Unit conversionµg/day → mg/hvia/ 24_000, then applied as a constant infusion rate:k₁ = GENERIC_K1 = 0.0075 h⁻¹.doseMGrepresents total reservoir content;rateMGhis unused.The two modes are mutually exclusive —
doseMGandRELEASE_RATE_UG_PER_DAYare not mathematically coupled in the current model. Dose mode does not derive a release rate; rate mode ignoresdoseMGentirely.No code changes made
Per explicit direction, no modifications were applied. The existing implementation is consistent, tested, and intentional.
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